NPVF_MOUSE
ID NPVF_MOUSE Reviewed; 188 AA.
AC Q9ESQ8; Q920A4;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Pro-FMRFamide-related neuropeptide VF;
DE AltName: Full=FMRFamide-related peptides;
DE Contains:
DE RecName: Full=Neuropeptide NPSF;
DE Contains:
DE RecName: Full=Neuropeptide RFRP-1;
DE Contains:
DE RecName: Full=Neuropeptide NPVF;
DE AltName: Full=Neuropeptide RFRP-2;
DE Flags: Precursor;
GN Name=Npvf; Synonyms=Rfrp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:BAB17673.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11025660; DOI=10.1038/35036326;
RA Hinuma S., Shintani Y., Fukusumi S., Iijima N., Matsumoto Y., Hosoya M.,
RA Fujii R., Watanabe T., Kikuchi K., Terao Y., Yano T., Yamamoto T.,
RA Kawamata Y., Habata Y., Asada M., Kitada C., Kurokawa T., Onda H.,
RA Nishimura O., Tanaka M., Ibata Y., Fujino M.;
RT "New neuropeptides containing carboxy-terminal RFamide and their receptor
RT in mammals.";
RL Nat. Cell Biol. 2:703-708(2000).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=11481330; DOI=10.1074/jbc.m105308200;
RA Liu Q., Guan X.-M., Martin W.J., McDonald T.P., Clements M.K., Jiang Q.,
RA Zeng Z., Jacobson M., Williams D.L. Jr., Yu H., Bomford D., Figueroa D.,
RA Mallee J., Wang R., Evans J., Gould R., Austin C.P.;
RT "Identification and characterization of novel mammalian neuropeptide FF-
RT like peptides that attenuate morphine-induced antinociception.";
RL J. Biol. Chem. 276:36961-36969(2001).
CC -!- FUNCTION: Neuropeptide RFRP-1 acts as a potent negative regulator of
CC gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF
CC efficiently inhibit forskolin-induced production of cAMP. Neuropeptide
CC NPVF blocks morphine-induced analgesia (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9ESQ8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ESQ8-2; Sequence=VSP_039963;
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000305}.
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DR EMBL; AB040289; BAB17673.1; -; mRNA.
DR EMBL; AF330058; AAK94202.2; -; mRNA.
DR CCDS; CCDS20133.1; -. [Q9ESQ8-1]
DR RefSeq; NP_068692.1; NM_021892.1. [Q9ESQ8-1]
DR AlphaFoldDB; Q9ESQ8; -.
DR STRING; 10090.ENSMUSP00000031853; -.
DR iPTMnet; Q9ESQ8; -.
DR PhosphoSitePlus; Q9ESQ8; -.
DR PaxDb; Q9ESQ8; -.
DR PRIDE; Q9ESQ8; -.
DR Antibodypedia; 50012; 28 antibodies from 9 providers.
DR DNASU; 60531; -.
DR Ensembl; ENSMUST00000031853; ENSMUSP00000031853; ENSMUSG00000029831. [Q9ESQ8-1]
DR GeneID; 60531; -.
DR KEGG; mmu:60531; -.
DR UCSC; uc009bxg.1; mouse. [Q9ESQ8-1]
DR CTD; 64111; -.
DR MGI; MGI:1926488; Npvf.
DR VEuPathDB; HostDB:ENSMUSG00000029831; -.
DR eggNOG; ENOG502S5H9; Eukaryota.
DR GeneTree; ENSGT00390000003271; -.
DR HOGENOM; CLU_120051_0_0_1; -.
DR InParanoid; Q9ESQ8; -.
DR OMA; NKMPHSA; -.
DR PhylomeDB; Q9ESQ8; -.
DR TreeFam; TF330935; -.
DR BioGRID-ORCS; 60531; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q9ESQ8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9ESQ8; protein.
DR Bgee; ENSMUSG00000029831; Expressed in dorsomedial nucleus of hypothalamus and 29 other tissues.
DR ExpressionAtlas; Q9ESQ8; baseline and differential.
DR Genevisible; Q9ESQ8; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
DR GO; GO:0032277; P:negative regulation of gonadotropin secretion; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISO:MGI.
DR GO; GO:0019233; P:sensory perception of pain; ISO:MGI.
DR InterPro; IPR026297; FMRFamide-related/fGRP.
DR PANTHER; PTHR14403; PTHR14403; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PROPEP 27..57
FT /id="PRO_0000009927"
FT PEPTIDE 58..94
FT /note="Neuropeptide NPSF"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009928"
FT PEPTIDE 83..94
FT /note="Neuropeptide RFRP-1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000401485"
FT PROPEP 97..106
FT /id="PRO_0000009929"
FT PEPTIDE 108..125
FT /note="Neuropeptide NPVF"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009930"
FT PROPEP 128..188
FT /id="PRO_0000009931"
FT REGION 116..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 94
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT MOD_RES 125
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT VAR_SEQ 173..188
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11481330"
FT /id="VSP_039963"
SQ SEQUENCE 188 AA; 21065 MW; 72090CB25E8F40DC CRC64;
MEIISLKRFI LLTVATSSFL TSNTFCTDEF MMPHFHSKEG DGKYSQLRGI PKGEKERSVS
FQELKDWGAK NVIKMSPAPA NKVPHSAANL PLRFGRTIDE KRSPAARVNM EAGTRSHFPS
LPQRFGRTTA RSPKTPADLP QKPLHSLGSS ELLYVMICQH QEIQSPGGKR TRRGAFVETD
DAERKPEK
