NPW_HUMAN
ID NPW_HUMAN Reviewed; 165 AA.
AC Q8N729;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Neuropeptide W;
DE AltName: Full=Preproprotein L8;
DE Short=hPPL8;
DE Contains:
DE RecName: Full=Neuropeptide W-23;
DE Short=NPW23;
DE Short=hL8;
DE Contains:
DE RecName: Full=Neuropeptide W-30;
DE Short=NPW30;
DE Short=hL8C;
DE Flags: Precursor;
GN Name=NPW; Synonyms=PPL8, PPNPW;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND SYNTHESIS OF NPW23 AND
RP NPW30.
RX PubMed=12130646; DOI=10.1074/jbc.m205337200;
RA Shimomura Y., Harada M., Goto M., Sugo T., Matsumoto Y., Abe M.,
RA Watanabe T., Asami T., Kitada C., Mori M., Onda H., Fujino M.;
RT "Identification of neuropeptide W as the endogenous ligand for orphan G-
RT protein-coupled receptors GPR7 and GPR8.";
RL J. Biol. Chem. 277:35826-35832(2002).
RN [2]
RP CHARACTERIZATION.
RX PubMed=12401809; DOI=10.1074/jbc.m206396200;
RA Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V.,
RA Lucchetti J., Detheux M., Parmentier M.;
RT "Identification of natural ligands for the orphan G protein-coupled
RT receptors GPR7 and GPR8.";
RL J. Biol. Chem. 278:776-783(2003).
CC -!- FUNCTION: Plays a regulatory role in the organization of neuroendocrine
CC signals accessing the anterior pituitary gland. Stimulates water
CC drinking and food intake. May play a role in the hypothalamic response
CC to stress (By similarity). NPW23 activates GPR7 and GPR8 more
CC efficiently than NPW30. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Detected at high levels in the substantia nigra,
CC fetal kidney and trachea; at lower levels in testis, uterus, ovary and
CC placenta. Not detectable in many regions of the central nervous system.
CC Also detected at high levels in lymphoblastic leukemia and colorectal
CC adenocarcinoma.
CC -!- SIMILARITY: Belongs to the neuropeptide B/W family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC07172.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB084276; BAC07172.1; ALT_INIT; mRNA.
DR CCDS; CCDS42102.1; -.
DR RefSeq; NP_001092926.2; NM_001099456.2.
DR AlphaFoldDB; Q8N729; -.
DR BioGRID; 129692; 43.
DR STRING; 9606.ENSP00000330070; -.
DR PhosphoSitePlus; Q8N729; -.
DR BioMuta; NPW; -.
DR jPOST; Q8N729; -.
DR MassIVE; Q8N729; -.
DR PaxDb; Q8N729; -.
DR PeptideAtlas; Q8N729; -.
DR PRIDE; Q8N729; -.
DR ProteomicsDB; 72259; -.
DR Antibodypedia; 54421; 98 antibodies from 16 providers.
DR DNASU; 283869; -.
DR Ensembl; ENST00000566435.4; ENSP00000456974.3; ENSG00000183971.10.
DR GeneID; 283869; -.
DR KEGG; hsa:283869; -.
DR MANE-Select; ENST00000566435.4; ENSP00000456974.3; NM_001099456.3; NP_001092926.2.
DR UCSC; uc059pez.1; human.
DR CTD; 283869; -.
DR DisGeNET; 283869; -.
DR GeneCards; NPW; -.
DR HGNC; HGNC:30509; NPW.
DR HPA; ENSG00000183971; Tissue enhanced (liver).
DR MIM; 607997; gene.
DR neXtProt; NX_Q8N729; -.
DR OpenTargets; ENSG00000183971; -.
DR PharmGKB; PA142671248; -.
DR VEuPathDB; HostDB:ENSG00000183971; -.
DR eggNOG; ENOG502SW0V; Eukaryota.
DR GeneTree; ENSGT00940000158204; -.
DR HOGENOM; CLU_121719_0_0_1; -.
DR InParanoid; Q8N729; -.
DR OMA; PSGAWYK; -.
DR OrthoDB; 1500150at2759; -.
DR PhylomeDB; Q8N729; -.
DR TreeFam; TF333179; -.
DR PathwayCommons; Q8N729; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; Q8N729; -.
DR BioGRID-ORCS; 283869; 13 hits in 1065 CRISPR screens.
DR ChiTaRS; NPW; human.
DR GeneWiki; NPW; -.
DR GenomeRNAi; 283869; -.
DR Pharos; Q8N729; Tbio.
DR PRO; PR:Q8N729; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8N729; protein.
DR Bgee; ENSG00000183971; Expressed in decidua and 89 other tissues.
DR ExpressionAtlas; Q8N729; baseline and differential.
DR Genevisible; Q8N729; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0007631; P:feeding behavior; IDA:HGNC-UCL.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:HGNC-UCL.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR013297; Neuropept_BW_pre.
DR InterPro; IPR013299; Neuropept_W_pre.
DR PANTHER; PTHR28553; PTHR28553; 1.
DR Pfam; PF15180; NPBW; 1.
DR PRINTS; PR01888; NROPEPTIDEBW.
DR PRINTS; PR01890; PPNRPEPTIDEW.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Neuropeptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT PEPTIDE 33..62
FT /note="Neuropeptide W-30"
FT /id="PRO_0000019843"
FT PEPTIDE 33..55
FT /note="Neuropeptide W-23"
FT /id="PRO_0000019844"
FT PROPEP 65..165
FT /evidence="ECO:0000255"
FT /id="PRO_0000019845"
FT REGION 106..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 149
FT /note="D -> A (in dbSNP:rs2286472)"
FT /id="VAR_050292"
SQ SEQUENCE 165 AA; 18048 MW; F426AF4B7FB6E604 CRC64;
MAWRPGERGA PASRPRLALL LLLLLLPLPS GAWYKHVASP RYHTVGRAAG LLMGLRRSPY
LWRRALRAAA GPLARDTLSP EPAAREAPLL LPSWVQELWE TRRRSSQAGI PVRAPRSPRA
PEPALEPESL DFSGAGQRLR RDVSRPAVDP AANRLGLPCL APGPF
