NPW_PIG
ID NPW_PIG Reviewed; 152 AA.
AC Q8MI35;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Neuropeptide W;
DE AltName: Full=Preproprotein L8;
DE Short=PPL8;
DE Contains:
DE RecName: Full=Neuropeptide W-23;
DE Short=NPW23;
DE AltName: Full=L8;
DE Contains:
DE RecName: Full=Neuropeptide W-30;
DE Short=NPW30;
DE AltName: Full=L8C;
DE Flags: Precursor;
GN Name=NPW; Synonyms=PPL8;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 33-52, AND SYNTHESIS OF
RP NPW23 AND NPW30.
RX PubMed=12130646; DOI=10.1074/jbc.m205337200;
RA Shimomura Y., Harada M., Goto M., Sugo T., Matsumoto Y., Abe M.,
RA Watanabe T., Asami T., Kitada C., Mori M., Onda H., Fujino M.;
RT "Identification of neuropeptide W as the endogenous ligand for orphan G-
RT protein-coupled receptors GPR7 and GPR8.";
RL J. Biol. Chem. 277:35826-35832(2002).
CC -!- FUNCTION: Plays a regulatory role in the organization of neuroendocrine
CC signals accessing the anterior pituitary gland. Stimulates water
CC drinking and food intake. May play a role in the hypothalamic response
CC to stress (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the neuropeptide B/W family. {ECO:0000305}.
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DR EMBL; AB084277; BAC07173.1; -; mRNA.
DR RefSeq; NP_998951.1; NM_213786.1.
DR AlphaFoldDB; Q8MI35; -.
DR STRING; 9823.ENSSSCP00000008582; -.
DR PaxDb; Q8MI35; -.
DR PRIDE; Q8MI35; -.
DR Ensembl; ENSSSCT00000068765; ENSSSCP00000072770; ENSSSCG00000048627.
DR Ensembl; ENSSSCT00005062497; ENSSSCP00005038628; ENSSSCG00005039103.
DR Ensembl; ENSSSCT00015039880; ENSSSCP00015015781; ENSSSCG00015030097.
DR Ensembl; ENSSSCT00025028935; ENSSSCP00025012279; ENSSSCG00025021302.
DR Ensembl; ENSSSCT00030052907; ENSSSCP00030024141; ENSSSCG00030038014.
DR Ensembl; ENSSSCT00035086507; ENSSSCP00035036043; ENSSSCG00035064290.
DR Ensembl; ENSSSCT00040082919; ENSSSCP00040036118; ENSSSCG00040060951.
DR Ensembl; ENSSSCT00045064101; ENSSSCP00045045258; ENSSSCG00045037174.
DR Ensembl; ENSSSCT00050107084; ENSSSCP00050047301; ENSSSCG00050077800.
DR Ensembl; ENSSSCT00055061534; ENSSSCP00055049389; ENSSSCG00055030827.
DR Ensembl; ENSSSCT00060109135; ENSSSCP00060048805; ENSSSCG00060078865.
DR Ensembl; ENSSSCT00065085406; ENSSSCP00065037327; ENSSSCG00065062268.
DR Ensembl; ENSSSCT00070055117; ENSSSCP00070046770; ENSSSCG00070027485.
DR GeneID; 396680; -.
DR KEGG; ssc:396680; -.
DR CTD; 283869; -.
DR eggNOG; ENOG502SW0V; Eukaryota.
DR GeneTree; ENSGT00940000158204; -.
DR HOGENOM; CLU_121719_0_0_1; -.
DR InParanoid; Q8MI35; -.
DR OrthoDB; 1414581at2759; -.
DR TreeFam; TF333179; -.
DR Proteomes; UP000008227; Chromosome 3.
DR Proteomes; UP000314985; Chromosome 3.
DR Bgee; ENSSSCG00000048627; Expressed in blood and 14 other tissues.
DR Genevisible; Q8MI35; SS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR013297; Neuropept_BW_pre.
DR InterPro; IPR013299; Neuropept_W_pre.
DR PANTHER; PTHR28553; PTHR28553; 1.
DR Pfam; PF15180; NPBW; 1.
DR PRINTS; PR01888; NROPEPTIDEBW.
DR PRINTS; PR01890; PPNRPEPTIDEW.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000269|PubMed:12130646"
FT PEPTIDE 33..62
FT /note="Neuropeptide W-30"
FT /id="PRO_0000019846"
FT PEPTIDE 33..55
FT /note="Neuropeptide W-23"
FT /id="PRO_0000019847"
FT PROPEP 65..152
FT /evidence="ECO:0000255"
FT /id="PRO_0000019848"
FT REGION 79..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 152 AA; 16347 MW; 454284DD448067E4 CRC64;
MGARGPGPGA TARRRLLALL LLLLLLPLPA RAWYKHTASP RYHTVGRAAG LLMGLRRSPY
MWRRALRPAA GPLAWDTFGQ DVPPRGPSAR NALSPGPAPR DAPLLPPGVQ TLWQVRRGSF
RSGIPVSAPR SPRARGSEPQ PELGASSWTS AE
