NPW_RAT
ID NPW_RAT Reviewed; 185 AA.
AC Q8K1M5;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Neuropeptide W;
DE AltName: Full=Preproprotein L8;
DE Short=PPL8;
DE Contains:
DE RecName: Full=Neuropeptide W-23;
DE Short=NPW23;
DE AltName: Full=L8;
DE Contains:
DE RecName: Full=Neuropeptide W-30;
DE Short=NPW30;
DE AltName: Full=L8C;
DE Flags: Precursor;
GN Name=Npw; Synonyms=Ppl8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RX PubMed=12130646; DOI=10.1074/jbc.m205337200;
RA Shimomura Y., Harada M., Goto M., Sugo T., Matsumoto Y., Abe M.,
RA Watanabe T., Asami T., Kitada C., Mori M., Onda H., Fujino M.;
RT "Identification of neuropeptide W as the endogenous ligand for orphan G-
RT protein-coupled receptors GPR7 and GPR8.";
RL J. Biol. Chem. 277:35826-35832(2002).
RN [2]
RP FUNCTION.
RX PubMed=12810535; DOI=10.1210/en.2002-0161;
RA Baker J.R., Cardinal K., Bober C., Taylor M.M., Samson W.K.;
RT "Neuropeptide W acts in brain to control prolactin, corticosterone, and
RT growth hormone release.";
RL Endocrinology 144:2816-2821(2003).
CC -!- FUNCTION: Plays a regulatory role in the organization of neuroendocrine
CC signals accessing the anterior pituitary gland. Stimulates water
CC drinking and food intake. May play a role in the hypothalamic response
CC to stress. When injected into the lateral cerebroventricle, it elevates
CC prolactin (PRL) and corticosterone and lowers growth hormone (GH)
CC release. {ECO:0000269|PubMed:12810535}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the neuropeptide B/W family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB084278; BAC07174.1; -; mRNA.
DR RefSeq; NP_695206.1; NM_153294.1.
DR AlphaFoldDB; Q8K1M5; -.
DR STRING; 10116.ENSRNOP00000016554; -.
DR PaxDb; Q8K1M5; -.
DR PRIDE; Q8K1M5; -.
DR Ensembl; ENSRNOT00000016554; ENSRNOP00000016554; ENSRNOG00000012390.
DR GeneID; 259224; -.
DR KEGG; rno:259224; -.
DR UCSC; RGD:727858; rat.
DR CTD; 283869; -.
DR RGD; 727858; Npw.
DR eggNOG; ENOG502SW0V; Eukaryota.
DR GeneTree; ENSGT00940000158204; -.
DR HOGENOM; CLU_121719_0_0_1; -.
DR InParanoid; Q8K1M5; -.
DR OMA; PSGAWYK; -.
DR OrthoDB; 1500150at2759; -.
DR PhylomeDB; Q8K1M5; -.
DR TreeFam; TF333179; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:Q8K1M5; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000012390; Expressed in stomach and 12 other tissues.
DR Genevisible; Q8K1M5; RN.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IMP:RGD.
DR GO; GO:0007631; P:feeding behavior; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IMP:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR013297; Neuropept_BW_pre.
DR InterPro; IPR013299; Neuropept_W_pre.
DR PANTHER; PTHR28553; PTHR28553; 1.
DR Pfam; PF15180; NPBW; 1.
DR PRINTS; PR01888; NROPEPTIDEBW.
DR PRINTS; PR01890; PPNRPEPTIDEW.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Neuropeptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..41
FT /evidence="ECO:0000255"
FT PEPTIDE 42..71
FT /note="Neuropeptide W-30"
FT /id="PRO_0000019849"
FT PEPTIDE 42..64
FT /note="Neuropeptide W-23"
FT /id="PRO_0000019850"
FT PROPEP 74..185
FT /evidence="ECO:0000255"
FT /id="PRO_0000019851"
SQ SEQUENCE 185 AA; 20231 MW; 2A4C82DFE0A8F6B9 CRC64;
MDLSALASSR EVRGPGPGAP VNRPLLPLLL LLLLLPLPAS AWYKHVASPR YHTVGRASGL
LMGLRRSPYL WRRALGGAAG PLVGLPGQMA RSALLLPSPG QELWEVRSRS SPAGLPVHAT
RSLRDLEGAG QPEQSLSFQS WTSAEPAARA FGETLRAQPW FLQQIIFADP VRLDDRLKNR
WRPRA
