NPY1R_BOVIN
ID NPY1R_BOVIN Reviewed; 383 AA.
AC Q1RMU8;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Neuropeptide Y receptor type 1;
DE Short=NPY1-R;
GN Name=NPY1R;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC114695; AAI14696.1; -; mRNA.
DR RefSeq; NP_001039363.1; NM_001045898.1.
DR RefSeq; XP_005207617.1; XM_005207560.3.
DR AlphaFoldDB; Q1RMU8; -.
DR SMR; Q1RMU8; -.
DR STRING; 9913.ENSBTAP00000055219; -.
DR PaxDb; Q1RMU8; -.
DR Ensembl; ENSBTAT00000066076; ENSBTAP00000055219; ENSBTAG00000047586.
DR Ensembl; ENSBTAT00000087149; ENSBTAP00000060918; ENSBTAG00000047586.
DR GeneID; 504813; -.
DR KEGG; bta:504813; -.
DR CTD; 4886; -.
DR VEuPathDB; HostDB:ENSBTAG00000047586; -.
DR VGNC; VGNC:32223; NPY1R.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000160268; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; Q1RMU8; -.
DR OMA; KRNNMMD; -.
DR OrthoDB; 609835at2759; -.
DR TreeFam; TF315303; -.
DR Reactome; R-BTA-375276; Peptide ligand-binding receptors.
DR Reactome; R-BTA-418594; G alpha (i) signalling events.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000047586; Expressed in vas deferens and 93 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0001602; F:pancreatic polypeptide receptor activity; IEA:Ensembl.
DR GO; GO:0001601; F:peptide YY receptor activity; IEA:Ensembl.
DR GO; GO:0007631; P:feeding behavior; IEA:Ensembl.
DR GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000351; NPY1_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR PANTHER; PTHR24235:SF24; PTHR24235:SF24; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01013; NRPEPTIDEY1R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..383
FT /note="Neuropeptide Y receptor type 1"
FT /id="PRO_0000282825"
FT TOPO_DOM 1..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..299
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..383
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 368
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21555"
FT LIPID 338
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 113..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 383 AA; 44291 MW; 1CCF6F147DBCCA14 CRC64;
MNSTSFSQVE NHSIYYNFSE KNSRFLAFEN DDCHLPLAMI FTLALAYGAV IILGVSGNLA
LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY TLMDHWVFGE AMCKLNPFVQ
CVSITVSIFS LVLIAVERHQ LIINPRGWRP NNRHAYVGIA VIWVLAVASS LPFLIYQVLT
DEPFQNVTLD AFKDKYVCFD KFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYVRLKR
RNSMMDKMRD NKYRSSEAKR INIMLLSIVV AFAVCWLPLT IFNTVFDWDH QIIATCNHNL
LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFSFCDF RSRDDDYETI AMSTMHTDVS
KTSLKQASPV ALKKIHTDDN EKI
