NPY1R_MOUSE
ID NPY1R_MOUSE Reviewed; 382 AA.
AC Q04573; Q61993;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Neuropeptide Y receptor type 1;
DE Short=NPY1-R;
GN Name=Npy1r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=1468559; DOI=10.1016/0014-5793(92)81490-d;
RA Eva C., Oberto A., Sprengel R., Genazzani E.;
RT "The murine NPY-1 receptor gene. Structure and delineation of tissue-
RT specific expression.";
RL FEBS Lett. 314:285-288(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8530415; DOI=10.1074/jbc.270.50.30102;
RA Nakamura M., Sakanaka C., Aoki Y., Ogasawara H., Tsuji T., Kodama H.,
RA Matsumoto T., Shimizu T., Noma M.;
RT "Identification of two isoforms of mouse neuropeptide Y-Y1 receptor
RT generated by alternative splicing. Isolation, genomic structure, and
RT functional expression of the receptors.";
RL J. Biol. Chem. 270:30102-30110(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM NPY1-R ALPHA).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=NPY1-R alpha;
CC IsoId=Q04573-1; Sequence=Displayed;
CC Name=NPY1-R beta;
CC IsoId=Q04573-2; Sequence=VSP_001912, VSP_001913;
CC -!- TISSUE SPECIFICITY: The alpha form is highly expressed in the brain,
CC heart, kidney, spleen, skeletal muscle, and lung, whereas the beta
CC receptor mRNA was not detected in these tissues. However, the beta form
CC is expressed in mouse embryonic developmental stage (7 and 11 days),
CC bone marrow cells and several hematopoietic cell lines.
CC -!- DEVELOPMENTAL STAGE: The beta form is expressed in embryonic
CC developmental stage (7 and 11 days). The beta form is an embryonic and
CC a bone marrow form of NPY1-R, which decreases in the expression during
CC development and differentiation.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; Z18280; CAA79157.1; -; Genomic_DNA.
DR EMBL; Z18281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; D63818; BAA09887.1; -; mRNA.
DR EMBL; D63819; BAA09888.1; -; mRNA.
DR EMBL; BC051420; AAH51420.1; -; mRNA.
DR CCDS; CCDS22336.1; -. [Q04573-1]
DR PIR; S27388; S27388.
DR RefSeq; NP_035064.1; NM_010934.4. [Q04573-1]
DR RefSeq; XP_006509657.1; XM_006509594.3. [Q04573-1]
DR RefSeq; XP_006509658.1; XM_006509595.3. [Q04573-1]
DR RefSeq; XP_006509659.1; XM_006509596.3.
DR RefSeq; XP_017168103.1; XM_017312614.1. [Q04573-1]
DR AlphaFoldDB; Q04573; -.
DR SMR; Q04573; -.
DR STRING; 10090.ENSMUSP00000045530; -.
DR BindingDB; Q04573; -.
DR ChEMBL; CHEMBL4739851; -.
DR GuidetoPHARMACOLOGY; 305; -.
DR GlyGen; Q04573; 3 sites.
DR iPTMnet; Q04573; -.
DR PhosphoSitePlus; Q04573; -.
DR PaxDb; Q04573; -.
DR PRIDE; Q04573; -.
DR ProteomicsDB; 293883; -. [Q04573-1]
DR Antibodypedia; 16963; 432 antibodies from 37 providers.
DR DNASU; 18166; -.
DR Ensembl; ENSMUST00000039303; ENSMUSP00000045530; ENSMUSG00000036437. [Q04573-1]
DR Ensembl; ENSMUST00000212588; ENSMUSP00000148417; ENSMUSG00000036437. [Q04573-1]
DR GeneID; 18166; -.
DR KEGG; mmu:18166; -.
DR UCSC; uc009lvt.2; mouse. [Q04573-1]
DR CTD; 4886; -.
DR MGI; MGI:104963; Npy1r.
DR VEuPathDB; HostDB:ENSMUSG00000036437; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000160268; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; Q04573; -.
DR OMA; KRNNMMD; -.
DR PhylomeDB; Q04573; -.
DR TreeFam; TF315303; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 18166; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Npy1r; mouse.
DR PRO; PR:Q04573; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q04573; protein.
DR Bgee; ENSMUSG00000036437; Expressed in ascending aorta and 105 other tissues.
DR ExpressionAtlas; Q04573; baseline and differential.
DR Genevisible; Q04573; MM.
DR GO; GO:0030424; C:axon; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0008021; C:synaptic vesicle; ISO:MGI.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IDA:MGI.
DR GO; GO:0001602; F:pancreatic polypeptide receptor activity; IDA:MGI.
DR GO; GO:0001601; F:peptide YY receptor activity; IDA:MGI.
DR GO; GO:0007631; P:feeding behavior; IMP:MGI.
DR GO; GO:0006006; P:glucose metabolic process; IMP:MGI.
DR GO; GO:0007626; P:locomotory behavior; IMP:MGI.
DR GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0046888; P:negative regulation of hormone secretion; ISO:MGI.
DR GO; GO:0003151; P:outflow tract morphogenesis; ISO:MGI.
DR GO; GO:0030432; P:peristalsis; ISO:MGI.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; ISO:MGI.
DR GO; GO:0008217; P:regulation of blood pressure; IMP:MGI.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
DR GO; GO:0019233; P:sensory perception of pain; IMP:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000351; NPY1_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR PANTHER; PTHR24235:SF24; PTHR24235:SF24; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01013; NRPEPTIDEY1R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate;
KW Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..382
FT /note="Neuropeptide Y receptor type 1"
FT /id="PRO_0000069921"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..210
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..298
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..382
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 367
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21555"
FT MOD_RES 375
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT LIPID 337
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 112..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VAR_SEQ 304..307
FT /note="CHLT -> LNMN (in isoform NPY1-R beta)"
FT /evidence="ECO:0000305"
FT /id="VSP_001912"
FT VAR_SEQ 308..382
FT /note="Missing (in isoform NPY1-R beta)"
FT /evidence="ECO:0000305"
FT /id="VSP_001913"
SQ SEQUENCE 382 AA; 44015 MW; CDCCF93E3ABB4D70 CRC64;
MNSTLFSKVE NHSIHYNASE NSPLLAFEND DCHLPLAVIF TLALAYGAVI ILGVSGNLAL
IIIILKQKEM RNVTNILIVN LSFSDLLVAV MCLPFTFVYT LMDHWVFGET MCKLNPFVQC
VSITVSIFSL VLIAVERHQL IINPRGWRPN NRHAYIGITV IWVLAVASSL PFVIYQILTD
EPFQNVSLAA FKDKYVCFDK FPSDSHRLSY TTLLLVLQYF GPLCFIFICY FKIYIRLKRR
NNMMDKIRDS KYRSSETKRI NIMLLSIVVA FAVCWLPLTI FNTVFDWNHQ IIATCNHNLL
FLLCHLTAMI STCVNPIFYG FLNKNFQRDL QFFFNFCDFR SRDDDYETIA MSTMHTDVSK
TSLKQASPVA FKKISMNDNE KV
