NPY2R_BOVIN
ID NPY2R_BOVIN Reviewed; 384 AA.
AC P79113;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Neuropeptide Y receptor type 2;
DE Short=NPY2-R;
DE AltName: Full=NPY-Y2 receptor;
DE Short=Y2 receptor;
GN Name=NPY2R;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Ammar D.A., Kolakowski L.F. Jr., Eadie D.M., Wong D.J., Ma Y.Y.,
RA Yang-Feng T.L., Thompson D.A.;
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U50144; AAB40600.1; -; mRNA.
DR RefSeq; NP_776826.1; NM_174401.2.
DR AlphaFoldDB; P79113; -.
DR SMR; P79113; -.
DR STRING; 9913.ENSBTAP00000022125; -.
DR PaxDb; P79113; -.
DR GeneID; 281943; -.
DR KEGG; bta:281943; -.
DR CTD; 4887; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P79113; -.
DR OrthoDB; 746515at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001358; NPY2_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01014; NRPEPTIDEY2R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..384
FT /note="Neuropeptide Y receptor type 2"
FT /id="PRO_0000069926"
FT TOPO_DOM 1..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..89
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..127
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..219
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..307
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..384
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 345
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 126..206
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 384 AA; 42943 MW; 468D19CBA8F29681 CRC64;
MKMGPLGAEA DENQTVEEMK VDQFGPGHTT LPGELAPDSE PELIDSTKLI EVQVVLILAY
CSIILLGVIG NSLVIHVVIK FKSMRTVTNF FIANLAVADL LVNTLCLPFT LTYTLMGEWK
MGPVLCHLVP YAQGLAVQVS TITLTVIALD RHRCIVYHLE SKISKQISFL IIGLAWGVSA
LLASPLAIFR EYSLIEIIPD FEIVACTEKW PGEEKGIYGT IYSLSSLLIL YVLPLGIISF
SYTRIWSKLK NHVSPGAAHD HYHQRRQKTT KMLVCVVVVF AVSWLPLHAF QLAVDIDSHV
LDLKEYKLIF TVFHIIAMCS TFANPLLYGW MNSNYRKAFL SAFRCEQRLD AIHSEVSVTF
KAKKHLQVTK NNGPNDSFTE TTNV
