ID   NPY2R_CAVPO             Reviewed;         381 AA.
AC   Q9Z2D5;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Neuropeptide Y receptor type 2;
DE            Short=NPY2-R;
DE   AltName: Full=NPY-Y2 receptor;
DE            Short=Y2 receptor;
GN   Name=NPY2R;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9802390; DOI=10.1016/s0167-0115(98)00049-4;
RA   Sharma P.S., Holmberg S.K., Eriksson H., Beck-Sickinger A.G., Grundemar L.,
RA   Larhammar D.;
RT   "Cloning and functional expression of the guinea pig neuropeptide Y Y2
RT   receptor.";
RL   Regul. Pept. 75:23-28(1998).
CC   -!- FUNCTION: Receptor for neuropeptide Y and peptide YY.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF072821; AAD13143.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9Z2D5; -.
DR   SMR; Q9Z2D5; -.
DR   STRING; 10141.ENSCPOP00000017761; -.
DR   BindingDB; Q9Z2D5; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   InParanoid; Q9Z2D5; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001358; NPY2_rcpt.
DR   InterPro; IPR000611; NPY_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01014; NRPEPTIDEY2R.
DR   PRINTS; PR01012; NRPEPTIDEYR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..381
FT                   /note="Neuropeptide Y receptor type 2"
FT                   /id="PRO_0000069927"
FT   TOPO_DOM        1..52
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..125
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..166
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..217
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        239..269
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..305
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        327..381
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           343
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        11
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        124..204
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   381 AA;  42343 MW;  D806B859A43ECACE CRC64;
     MGPIGTEADE NQTVEEIKVE PYGPGHTTPR GELAPDPEPE LIDSTKLTEV RVVLILAYCS
     IILLGVVGNS LVIHVVIKFK SMRTVTNFFI ANLAVADLLV NTLCLPFTLT YTLMGEWKMG
     PVLCHLVPYA QGLAVQVSTV TLTVIALDRH RCIVYHLDSK ISKQNSFLII GLAWGISALL
     ASPLAIFREY SLIEIIPDFE IVACTEKWPG EEKSIYGTVY SLSSLLILYV LPLGIISVSY
     VRIWSKLKNH VSPGAANDHY HQRRQKTTKM LVFVVVVFAV SWLPLHAFQL AVDIDSQVLD
     LKEYKLIFTV FHIIAMCSTF ANPLLYGWMN SNYRKAFLSA FRCQQRLDAI QSEVCVTGKA
     KTNVEVEKNH GAADSAEATN V