NPY2R_CHICK
ID NPY2R_CHICK Reviewed; 385 AA.
AC Q9DDN6;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Neuropeptide Y receptor type 2;
DE Short=NPY2-R;
DE AltName: Full=NPY-Y2 receptor;
DE Short=Y2 receptor;
GN Name=NPY2R;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11078884; DOI=10.1016/s0014-5793(00)02164-5;
RA Salaneck E., Holmberg S.K., Berglund M.M., Boswell T., Larhammar D.;
RT "Chicken neuropeptide Y receptor Y2: structural and pharmacological
RT differences to mammalian Y2.";
RL FEBS Lett. 484:229-234(2000).
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF309091; AAG37898.1; -; Genomic_DNA.
DR RefSeq; NP_001026299.1; NM_001031128.1.
DR RefSeq; XP_015140770.1; XM_015285284.1.
DR RefSeq; XP_015140771.1; XM_015285285.1.
DR AlphaFoldDB; Q9DDN6; -.
DR SMR; Q9DDN6; -.
DR STRING; 9031.ENSGALP00000015084; -.
DR PaxDb; Q9DDN6; -.
DR Ensembl; ENSGALT00000015100; ENSGALP00000015084; ENSGALG00000009280.
DR Ensembl; ENSGALT00000099583; ENSGALP00000072258; ENSGALG00000009280.
DR GeneID; 422405; -.
DR KEGG; gga:422405; -.
DR CTD; 4887; -.
DR VEuPathDB; HostDB:geneid_422405; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000155973; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; Q9DDN6; -.
DR OMA; CEMIILE; -.
DR OrthoDB; 746515at2759; -.
DR PhylomeDB; Q9DDN6; -.
DR TreeFam; TF315303; -.
DR Reactome; R-GGA-375276; Peptide ligand-binding receptors.
DR Reactome; R-GGA-418594; G alpha (i) signalling events.
DR PRO; PR:Q9DDN6; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000009280; Expressed in brain and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0097730; C:non-motile cilium; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0001601; F:peptide YY receptor activity; IEA:Ensembl.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0003214; P:cardiac left ventricle morphogenesis; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001358; NPY2_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01014; NRPEPTIDEY2R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..385
FT /note="Neuropeptide Y receptor type 2"
FT /id="PRO_0000069934"
FT TOPO_DOM 1..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..90
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..128
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..221
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..273
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..308
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..385
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 346
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 127..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 385 AA; 43509 MW; 60A09B314E665B62 CRC64;
MGPLEAIGEE NQTDEMKMEL FTKLYLPRYT TPVSELALDP KPELKDSTTL VEVQIILIFA
YCSIILLGVI GNSLVIHVII KFKSMRTVTN FFIANLAVAD LLVNTLCLPF TLVYTLLGEW
KLGPVLCHLV PYAQALAVHV STVTLTVIAL DRHRCIVYHL ESKISKRISF LIIGVAWAVS
ALLASPLAIF REYSLIEIIP DFKIVVCSEK WPGEGQLNYG TIYSVSMLLI QYVLPLAIIS
YAYTRIWTKL KNHVSPGAGN DHYHHRRQKT TKMLVCVVVV FAVSWLPFHA FQLVSDIDSQ
VLDLKEYKLI YTVFHVIAMC STFANPLLYG WMNNNYRTAF LTAFQCEQRL DSIHPEVSAA
FKARKKLEAK KSQFPGDSFT QPTNV
