NPY2R_HUMAN
ID NPY2R_HUMAN Reviewed; 381 AA.
AC P49146; Q13281; Q13457; Q4W5G7; Q6AZZ6; Q9UE67;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Neuropeptide Y receptor type 2;
DE Short=NPY2-R;
DE AltName: Full=NPY-Y2 receptor;
DE Short=Y2 receptor;
GN Name=NPY2R;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hippocampus;
RX PubMed=7592910; DOI=10.1074/jbc.270.45.26758;
RA Gerald C., Walker M.W., Vaysse P.J.-J., He C., Branchek T.A.,
RA Weinshank R.L.;
RT "Expression cloning and pharmacological characterization of a human
RT hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.";
RL J. Biol. Chem. 270:26758-26761(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=8632753;
RA Gehlert D.R., Beavers L.S., Johnson D., Gackenheimer S.L., Schober D.A.,
RA Gadski R.A.;
RT "Expression cloning of a human brain neuropeptide Y Y2 receptor.";
RL Mol. Pharmacol. 49:224-228(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7559383; DOI=10.1074/jbc.270.39.22661;
RA Rose P.M., Fernandes P., Lynch J.S., Frazier S.T., Fisher S.M.,
RA Kodukula K., Kienzle B., Seethala R.;
RT "Cloning and functional expression of a cDNA encoding a human type 2
RT neuropeptide Y receptor.";
RL J. Biol. Chem. 270:22661-22664(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8643460; DOI=10.1073/pnas.93.10.4661;
RA Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F.,
RA Karbon W.;
RT "Cloning and functional expression of cDNAs encoding human and rat
RT pancreatic polypeptide receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:4661-4665(1996).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8975716; DOI=10.1006/geno.1996.0642;
RA Ammar D.A., Eadie D.M., Wong D.J., Ma Y.-Y., Kolakowski L.F. Jr.,
RA Yang-Feng T.L., Thompson D.A.;
RT "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R)
RT and localization to the chromosome 4q region containing the type 1
RT neuropeptide Y receptor gene.";
RL Genomics 38:392-398(1996).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Zastawny R.L.;
RT "Human neuropeptide Y Y2 receptor gene.";
RL Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank order of
CC affinity of this receptor for pancreatic polypeptides is PYY > NPY >
CC PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY >
CC PP, [Pro-34] PYY and NPY free acid.
CC -!- INTERACTION:
CC P49146; P10082: PYY; NbExp=2; IntAct=EBI-6655721, EBI-6655667;
CC P49146; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-6655721, EBI-11988865;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: High levels in amygdala, corpus callosum,
CC hippocampus and subthalamic nucleus. Also detectable in caudate
CC nucleus, hypothalamus and substantia nigra.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U36269; AAC50281.1; -; mRNA.
DR EMBL; U42766; AAB04120.1; -; mRNA.
DR EMBL; U32500; AAA93170.1; -; mRNA.
DR EMBL; U42389; AAB07760.1; -; mRNA.
DR EMBL; U50146; AAC51115.1; -; Genomic_DNA.
DR EMBL; U76254; AAD00248.1; -; Genomic_DNA.
DR EMBL; AY236540; AAO92062.1; -; Genomic_DNA.
DR EMBL; AC104407; AAY40940.1; -; Genomic_DNA.
DR EMBL; CH471056; EAX04901.1; -; Genomic_DNA.
DR EMBL; BC075053; AAH75053.2; -; mRNA.
DR EMBL; BC075052; AAH75052.2; -; mRNA.
DR CCDS; CCDS3791.1; -.
DR PIR; I39187; I39187.
DR RefSeq; NP_000901.1; NM_000910.3.
DR RefSeq; XP_005263090.1; XM_005263033.4.
DR RefSeq; XP_005263091.1; XM_005263034.4.
DR AlphaFoldDB; P49146; -.
DR BMRB; P49146; -.
DR SMR; P49146; -.
DR BioGRID; 110947; 76.
DR IntAct; P49146; 57.
DR STRING; 9606.ENSP00000332591; -.
DR BindingDB; P49146; -.
DR ChEMBL; CHEMBL4018; -.
DR DrugBank; DB00847; Cysteamine.
DR DrugBank; DB05045; Obinepitide.
DR DrugBank; DB05004; Peptide YY (3-36).
DR DrugCentral; P49146; -.
DR GuidetoPHARMACOLOGY; 306; -.
DR TCDB; 9.A.14.13.33; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; P49146; 1 site.
DR iPTMnet; P49146; -.
DR PhosphoSitePlus; P49146; -.
DR BioMuta; NPY2R; -.
DR DMDM; 1352610; -.
DR EPD; P49146; -.
DR jPOST; P49146; -.
DR MassIVE; P49146; -.
DR PaxDb; P49146; -.
DR PeptideAtlas; P49146; -.
DR PRIDE; P49146; -.
DR ProteomicsDB; 55966; -.
DR Antibodypedia; 2964; 333 antibodies from 39 providers.
DR DNASU; 4887; -.
DR Ensembl; ENST00000329476.4; ENSP00000332591.3; ENSG00000185149.6.
DR Ensembl; ENST00000506608.1; ENSP00000426366.1; ENSG00000185149.6.
DR GeneID; 4887; -.
DR KEGG; hsa:4887; -.
DR MANE-Select; ENST00000329476.4; ENSP00000332591.3; NM_000910.4; NP_000901.1.
DR UCSC; uc003ioq.3; human.
DR CTD; 4887; -.
DR DisGeNET; 4887; -.
DR GeneCards; NPY2R; -.
DR HGNC; HGNC:7957; NPY2R.
DR HPA; ENSG00000185149; Group enriched (brain, breast).
DR MIM; 162642; gene.
DR neXtProt; NX_P49146; -.
DR OpenTargets; ENSG00000185149; -.
DR PharmGKB; PA31741; -.
DR VEuPathDB; HostDB:ENSG00000185149; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000155973; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; P49146; -.
DR OMA; CEMIILE; -.
DR OrthoDB; 746515at2759; -.
DR PhylomeDB; P49146; -.
DR TreeFam; TF315303; -.
DR PathwayCommons; P49146; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; P49146; -.
DR SIGNOR; P49146; -.
DR BioGRID-ORCS; 4887; 7 hits in 1071 CRISPR screens.
DR ChiTaRS; NPY2R; human.
DR GeneWiki; Neuropeptide_Y_receptor_Y2; -.
DR GenomeRNAi; 4887; -.
DR Pharos; P49146; Tchem.
DR PRO; PR:P49146; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; P49146; protein.
DR Bgee; ENSG00000185149; Expressed in cranial nerve II and 83 other tissues.
DR Genevisible; P49146; HS.
DR GO; GO:0005929; C:cilium; IDA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0097730; C:non-motile cilium; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005246; F:calcium channel regulator activity; TAS:ProtInc.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; TAS:ProtInc.
DR GO; GO:0001601; F:peptide YY receptor activity; IEA:Ensembl.
DR GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0003214; P:cardiac left ventricle morphogenesis; IMP:BHF-UCL.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007626; P:locomotory behavior; TAS:ProtInc.
DR GO; GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001358; NPY2_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01014; NRPEPTIDEY2R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..381
FT /note="Neuropeptide Y receptor type 2"
FT /id="PRO_0000069928"
FT TOPO_DOM 1..51
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..124
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..304
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 342
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 123..203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 134
FT /note="V -> A (in Ref. 3; AAA93170)"
FT /evidence="ECO:0000305"
FT CONFLICT 172
FT /note="A -> G (in Ref. 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="G -> R (in Ref. 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="A -> P (in Ref. 4; AAB07760)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="G -> A (in Ref. 4; AAB07760)"
FT /evidence="ECO:0000305"
FT CONFLICT 248
FT /note="N -> S (in Ref. 6; AAD00248)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="H -> Y (in Ref. 6; AAD00248)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 381 AA; 42731 MW; 7D018C0169597BC7 CRC64;
MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ VVLILAYCSI
ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN TLCLPFTLTY TLMGEWKMGP
VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR CIVYHLESKI SKRISFLIIG LAWGISALLA
SPLAIFREYS LIEIIPDFEI VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT
RIWSKLKNHV SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH SEVSVTFKAK
KNLEVRKNSG PNDSFTEATN V
