ID   NPY2_CONBE              Reviewed;          37 AA.
AC   P0CJ23;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Neuropeptide Y2-like conopeptide;
DE            Short=Cono-NPY2 {ECO:0000303|PubMed:20705590};
DE            Short=NPY2-like conopeptide;
OS   Conus betulinus (Beech cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dendroconus.
OX   NCBI_TaxID=89764;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, BIOASSAY, MASS SPECTROMETRY, AMIDATION AT
RP   TYR-37, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=20705590; DOI=10.1093/abbs/gmq042;
RA   Wu X., Shao X., Guo Z.Y., Chi C.W.;
RT   "Identification of neuropeptide Y-like conopeptides from the venom of Conus
RT   betulinus.";
RL   Acta Biochim. Biophys. Sin. 42:502-505(2010).
CC   -!- FUNCTION: Causes hyperactivity such as jumping, rapid circling and tail
CC       flicking, after intraventicular injection into mouse brain.
CC       {ECO:0000269|PubMed:20705590}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20705590}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:20705590}.
CC   -!- MASS SPECTROMETRY: Mass=4364.0; Method=Unknown;
CC       Evidence={ECO:0000269|PubMed:20705590};
CC   -!- MISCELLANEOUS: The mature peptide does not contain cysteine residue.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CJ23; -.
DR   SMR; P0CJ23; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   Pfam; PF00159; Hormone_3; 1.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neurotoxin; Secreted; Toxin.
FT   CHAIN           1..37
FT                   /note="Neuropeptide Y2-like conopeptide"
FT                   /evidence="ECO:0000269|PubMed:20705590"
FT                   /id="PRO_0000405963"
FT   MOD_RES         37
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000305|PubMed:20705590"
SQ   SEQUENCE   37 AA;  4365 MW;  A6EA8605EE41D972 CRC64;
     TVSDPPARPA VFHSREELMN YVRELNLYFA IVGRPRY