NPY42_HUMAN
ID NPY42_HUMAN Reviewed; 375 AA.
AC P0DQD5;
DT 10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 1.
DT 03-AUG-2022, entry version 20.
DE RecName: Full=Neuropeptide Y receptor type 4-2 {ECO:0000305};
GN Name=NPY4R2 {ECO:0000312|HGNC:HGNC:52383};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank order of
CC affinity of this receptor for pancreatic polypeptides is PP, PP (2-36)
CC and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY >
CC NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free
CC acid. {ECO:0000250|UniProtKB:P50391}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AC245041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS81459.1; -.
DR RefSeq; NP_001265724.1; NM_001278795.1.
DR RefSeq; XP_005277701.1; XM_005277644.3.
DR RefSeq; XP_006717608.1; XM_006717545.3.
DR RefSeq; XP_011537416.1; XM_011539114.2.
DR RefSeq; XP_011537417.1; XM_011539115.2.
DR RefSeq; XP_011547675.1; XM_011549373.2.
DR RefSeq; XP_011547676.1; XM_011549374.2.
DR RefSeq; XP_011547677.1; XM_011549375.2.
DR RefSeq; XP_011547678.1; XM_011549376.2.
DR RefSeq; XP_016854962.1; XM_016999473.1.
DR RefSeq; XP_016854963.1; XM_016999474.1.
DR RefSeq; XP_016870952.1; XM_017015463.1.
DR RefSeq; XP_016870953.1; XM_017015464.1.
DR AlphaFoldDB; P0DQD5; -.
DR SMR; P0DQD5; -.
DR STRING; 9606.ENSP00000363431; -.
DR BindingDB; P0DQD5; -.
DR GlyGen; P0DQD5; 4 sites.
DR PeptideAtlas; P0DQD5; -.
DR Ensembl; ENST00000576178.6; ENSP00000490174.1; ENSG00000264717.5.
DR Ensembl; ENST00000613306.1; ENSP00000489924.1; ENSG00000264717.5.
DR Ensembl; ENST00000671787.1; ENSP00000500673.1; ENSG00000288157.1.
DR Ensembl; ENST00000671991.1; ENSP00000499999.1; ENSG00000288157.1.
DR GeneID; 100996758; -.
DR KEGG; hsa:100996758; -.
DR MANE-Select; ENST00000576178.7; ENSP00000490174.1; NM_001395253.1; NP_001382182.1.
DR CTD; 100996758; -.
DR DisGeNET; 100996758; -.
DR GeneCards; NPY4R2; -.
DR HGNC; HGNC:52383; NPY4R2.
DR HPA; ENSG00000264717; Tissue enhanced (intestine).
DR neXtProt; NX_P0DQD5; -.
DR VEuPathDB; HostDB:ENSG00000264717; -.
DR OMA; FTVVYTM; -.
DR PRO; PR:P0DQD5; -.
DR Proteomes; UP000005640; Chromosome 10.
DR Bgee; ENSG00000264717; Expressed in colonic epithelium and 43 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0001602; F:pancreatic polypeptide receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001933; NPY4_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR PANTHER; PTHR24235:SF25; PTHR24235:SF25; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01015; NRPEPTIDEY4R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..375
FT /note="Neuropeptide Y receptor type 4-2"
FT /id="PRO_0000446660"
FT TOPO_DOM 1..39
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 40..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 88..108
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..116
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..212
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 264..284
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..301
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 302..322
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT LIPID 340
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..201
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 375 AA; 42195 MW; 0081DBA51436EE22 CRC64;
MNTSHLLALL LPKSPQGENR SKPLGTPYNF SEHCQDSVDV MVFIVTSYSI ETVVGVLGNL
CLMCVTVRQK EKANVTNLLI ANLAFSDFLM CLLCQPLTAV YTIMDYWIFG ETLCKMSAFI
QCMSVTVSIL SLVLVALERH QLIINPTGWK PSISQAYLGI VLIWVIACVL SLPFLANSIL
ENVFHKNHSK ALEFLADKVV CTESWPLAHH RTIYTTFLLL FQYCLPLGFI LVCYARIYRR
LQRQGRVFHK GTYSLRAGHM KQVNVVLVVM VVAFAVLWLP LHVFNSLEDW HHEAIPICHG
NLIFLVCHLL AMASTCVNPF IYGFLNTNFK KEIKALVLTC QQSAPLEESE HLPLSTVHTE
VSKGSLRLSG RSNPI
