NPY5R_CANLF
ID NPY5R_CANLF Reviewed; 446 AA.
AC O62729;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Neuropeptide Y receptor type 5;
DE Short=NPY5-R;
DE AltName: Full=NPY-Y5 receptor;
DE Short=NPYY5-R;
DE Short=Y5 receptor;
GN Name=NPY5R; Synonyms=NPY5;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9802393; DOI=10.1016/s0167-0115(98)00052-4;
RA Borowsky B., Walker M.W., Bard J., Weinshank R.L., Laz T.M., Vaysse P.,
RA Branchek T.A., Gerald C.;
RT "Molecular biology and pharmacology of multiple NPY Y5 receptor species
RT homologs.";
RL Regul. Pept. 75:45-53(1998).
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity of
CC this receptor is mediated by G proteins that inhibit adenylate cyclase
CC activity. Seems to be associated with food intake. Could be involved in
CC feeding disorders (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF049328; AAC17838.1; -; mRNA.
DR RefSeq; NP_001003118.1; NM_001003118.1.
DR AlphaFoldDB; O62729; -.
DR SMR; O62729; -.
DR STRING; 9615.ENSCAFP00000036624; -.
DR PaxDb; O62729; -.
DR Ensembl; ENSCAFT00845011461; ENSCAFP00845008953; ENSCAFG00845006457.
DR GeneID; 403712; -.
DR KEGG; cfa:403712; -.
DR CTD; 4889; -.
DR VEuPathDB; HostDB:ENSCAFG00845006457; -.
DR VGNC; VGNC:54273; NPY5R.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161766; -.
DR InParanoid; O62729; -.
DR OrthoDB; 609835at2759; -.
DR Proteomes; UP000002254; Chromosome 15.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0001602; F:pancreatic polypeptide receptor activity; IBA:GO_Central.
DR GO; GO:0001601; F:peptide YY receptor activity; IBA:GO_Central.
DR GO; GO:0003214; P:cardiac left ventricle morphogenesis; IEA:Ensembl.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR CDD; cd15398; 7tmA_NPY5R; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000393; NPY5_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01016; NRPEPTIDEY5R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..446
FT /note="Neuropeptide Y receptor type 5"
FT /id="PRO_0000069938"
FT TOPO_DOM 1..42
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..407
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 429..446
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 442
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 446 AA; 51013 MW; 5CAC8D2FCF5D254A CRC64;
MDLELQDFYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF VSLLGFMGNL
LILMALMRKR NQKTMVNFLI GNLAFSDILV VLFCSPFTLT SVLLDQWMFG KVMCHIMPFL
QCVSVLVSTL ILISIAIVRY HMIKHPISNN LTANHGYFLI ATVWTLGFAI CSPLPVFHSL
VELQETFDSA LLSSRYLCVE SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC
GLSNKENKLE ENEMINLTLQ PFKKSGPQVK LSSSHKWSYS FIRKHRRRYS KKTACVLPAP
ARPPQENHSR MLPENFGSVR SQHSSSSKFI PGVPTCFEVK PEENSDVHDM RVNRSIMRIK
KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL
NPILYGFLNN GIKADLISLI QCLHMS
