NPY5R_MOUSE
ID NPY5R_MOUSE Reviewed; 466 AA.
AC O70342; O35380; Q9JMK1;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Neuropeptide Y receptor type 5;
DE Short=NPY5-R;
DE AltName: Full=NPY-Y5 receptor;
DE Short=NPYY5-R;
DE Short=Y5 receptor;
GN Name=Npy5r; Synonyms=Npy5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9802393; DOI=10.1016/s0167-0115(98)00052-4;
RA Borowsky B., Walker M.W., Bard J., Weinshank R.L., Laz T.M., Vaysse P.,
RA Branchek T.A., Gerald C.;
RT "Molecular biology and pharmacology of multiple NPY Y5 receptor species
RT homologs.";
RL Regul. Pept. 75:45-53(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129/Sv; TISSUE=Brain;
RA Chen H., Adams S., McWhinnie E., Bayne M., Gadski R., Zastawny R.;
RT "Mouse neuropeptide Y Y5 receptor characterized by repeat sequence in
RT extracellular domain.";
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9315606; DOI=10.1016/s0005-2736(97)00131-4;
RA Nakamura M., Yokoyama M., Watanabe H., Matsumoto T.;
RT "Molecular cloning, organization and localization of the gene for the mouse
RT neuropeptide Y-Y5 receptor.";
RL Biochim. Biophys. Acta 1328:83-89(1997).
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity of
CC this receptor is mediated by G proteins that inhibit adenylate cyclase
CC activity. Seems to be associated with food intake. Could be involved in
CC feeding disorders (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF049329; AAC17839.1; -; mRNA.
DR EMBL; AF022948; AAB81829.1; -; Genomic_DNA.
DR EMBL; AB001346; BAA89538.1; -; mRNA.
DR CCDS; CCDS22335.1; -.
DR RefSeq; NP_057917.2; NM_016708.3.
DR RefSeq; XP_006509661.1; XM_006509598.3.
DR RefSeq; XP_006509662.1; XM_006509599.3.
DR AlphaFoldDB; O70342; -.
DR SMR; O70342; -.
DR STRING; 10090.ENSMUSP00000065157; -.
DR BindingDB; O70342; -.
DR ChEMBL; CHEMBL3802; -.
DR GlyGen; O70342; 4 sites.
DR PhosphoSitePlus; O70342; -.
DR SwissPalm; O70342; -.
DR PaxDb; O70342; -.
DR PRIDE; O70342; -.
DR ProteomicsDB; 253006; -.
DR Antibodypedia; 2946; 276 antibodies from 33 providers.
DR DNASU; 18168; -.
DR Ensembl; ENSMUST00000070810; ENSMUSP00000065157; ENSMUSG00000044014.
DR Ensembl; ENSMUST00000211920; ENSMUSP00000148410; ENSMUSG00000044014.
DR Ensembl; ENSMUST00000212563; ENSMUSP00000148589; ENSMUSG00000044014.
DR GeneID; 18168; -.
DR KEGG; mmu:18168; -.
DR UCSC; uc009lvr.2; mouse.
DR CTD; 4889; -.
DR MGI; MGI:108082; Npy5r.
DR VEuPathDB; HostDB:ENSMUSG00000044014; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161766; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; O70342; -.
DR OMA; CHVMPFL; -.
DR OrthoDB; 609835at2759; -.
DR PhylomeDB; O70342; -.
DR TreeFam; TF315303; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 18168; 2 hits in 71 CRISPR screens.
DR PRO; PR:O70342; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; O70342; protein.
DR Bgee; ENSMUSG00000044014; Expressed in lumbar subsegment of spinal cord and 63 other tissues.
DR ExpressionAtlas; O70342; baseline and differential.
DR Genevisible; O70342; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0043005; C:neuron projection; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IDA:MGI.
DR GO; GO:0001602; F:pancreatic polypeptide receptor activity; IDA:MGI.
DR GO; GO:0001601; F:peptide YY receptor activity; IDA:MGI.
DR GO; GO:0007568; P:aging; IEA:Ensembl.
DR GO; GO:0003214; P:cardiac left ventricle morphogenesis; ISO:MGI.
DR GO; GO:0007268; P:chemical synaptic transmission; IMP:MGI.
DR GO; GO:0042755; P:eating behavior; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0060112; P:generation of ovulation cycle rhythm; ISO:MGI.
DR GO; GO:0002865; P:negative regulation of acute inflammatory response to antigenic stimulus; ISO:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR GO; GO:0014050; P:negative regulation of glutamate secretion; ISO:MGI.
DR GO; GO:0032229; P:negative regulation of synaptic transmission, GABAergic; ISO:MGI.
DR GO; GO:0003151; P:outflow tract morphogenesis; ISO:MGI.
DR GO; GO:0002675; P:positive regulation of acute inflammatory response; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISO:MGI.
DR CDD; cd15398; 7tmA_NPY5R; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000393; NPY5_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01016; NRPEPTIDEY5R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..466
FT /note="Neuropeptide Y receptor type 5"
FT /id="PRO_0000069940"
FT TOPO_DOM 1..63
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..98
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..177
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..229
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..389
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 411..427
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 449..466
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 323..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 462
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 135..219
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 195
FT /note="L -> F (in Ref. 1; AAC17839)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="K -> Q (in Ref. 3; BAA89538)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 466 AA; 52785 MW; B157F236EF2D4385 CRC64;
MEVKLEEHFN KTFVTENNTA ASQNTASPAW EDYRGTENNT SAARNTAFPV WEDYRGSVDD
LQYFLIGLYT FVSLLGFMGN LLILMAVMKK RNQKTTVNFL IGNLAFSDIL VVLFCSPFTL
TSVLLDQWMF GKAMCHIMPF LQCVSVLVST LILISIAIVR YHMIKHPISN NLTANHGYFL
IATVWTLGFA ICSPLPVFHS LVELKETFGS ALLSSKYLCV ESWPSDSYRI AFTISLLLVQ
YILPLVCLTV SHTSVCRSIS CGLSHKENRL EENEMINLTL HPSKKSRDQA KPPSTQKWSY
SFIRKHRRRY SKKTACVLPA PAGPSQEKHL TVPENPGSVR SQLSPSSKVI PGVPICFEVK
PEESSDAQEM RVKRSLTRIK KRSRSVFYRL TILILVFAVS WMPLHVFHVV TDFNDNLISN
RHFKLVYCIC HLLGMMSCCL NPILYGFLNN GIKADLRALI HCLHMS
