NPY5R_PIG
ID NPY5R_PIG Reviewed; 446 AA.
AC O97969;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Neuropeptide Y receptor type 5;
DE Short=NPY5-R;
DE AltName: Full=NPY-Y5 receptor;
DE Short=NPYY5-R;
DE Short=Y5 receptor;
GN Name=NPY5R; Synonyms=NPYR5;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Wraith A., Tornsten A., Chardon P., Harbitz I., Chowdhary B.P.,
RA Andersson L., Larhammar D.;
RT "Porcine NPY receptors NPY1R, NPY2R and NPY5R: cloning, mapping and
RT comparative analysis.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Large white X Duroc; TISSUE=Kidney;
RA Ito Y., Minezawa M.;
RT "Sus scrofa gene for neuropeptide Y receptor type 5, complete cds.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity of
CC this receptor is mediated by G proteins that inhibit adenylate cyclase
CC activity. Seems to be associated with food intake. Could be involved in
CC feeding disorders (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF106083; AAD13778.1; -; Genomic_DNA.
DR EMBL; AB019185; BAA34055.1; -; Genomic_DNA.
DR RefSeq; XP_003129059.1; XM_003129011.3.
DR RefSeq; XP_013834158.1; XM_013978704.1.
DR AlphaFoldDB; O97969; -.
DR SMR; O97969; -.
DR STRING; 9823.ENSSSCP00000009481; -.
DR PaxDb; O97969; -.
DR PRIDE; O97969; -.
DR Ensembl; ENSSSCT00000009732; ENSSSCP00000009481; ENSSSCG00000008889.
DR Ensembl; ENSSSCT00005041090; ENSSSCP00005025144; ENSSSCG00005025973.
DR Ensembl; ENSSSCT00015033162; ENSSSCP00015013183; ENSSSCG00015025007.
DR Ensembl; ENSSSCT00025042416; ENSSSCP00025018053; ENSSSCG00025031195.
DR Ensembl; ENSSSCT00030069421; ENSSSCP00030031691; ENSSSCG00030049796.
DR Ensembl; ENSSSCT00035006321; ENSSSCP00035002216; ENSSSCG00035005031.
DR Ensembl; ENSSSCT00040000658; ENSSSCP00040000161; ENSSSCG00040000574.
DR Ensembl; ENSSSCT00045028695; ENSSSCP00045019847; ENSSSCG00045016893.
DR Ensembl; ENSSSCT00055011528; ENSSSCP00055009123; ENSSSCG00055005921.
DR Ensembl; ENSSSCT00060083863; ENSSSCP00060036352; ENSSSCG00060061453.
DR Ensembl; ENSSSCT00065012071; ENSSSCP00065004931; ENSSSCG00065009060.
DR Ensembl; ENSSSCT00070024823; ENSSSCP00070020561; ENSSSCG00070012727.
DR GeneID; 100517770; -.
DR KEGG; ssc:100517770; -.
DR CTD; 4889; -.
DR VGNC; VGNC:90866; NPY5R.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161766; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; O97969; -.
DR OMA; CHVMPFL; -.
DR OrthoDB; 609835at2759; -.
DR TreeFam; TF315303; -.
DR Reactome; R-SSC-375276; Peptide ligand-binding receptors.
DR Reactome; R-SSC-418594; G alpha (i) signalling events.
DR Proteomes; UP000008227; Chromosome 8.
DR Proteomes; UP000314985; Chromosome 8.
DR Bgee; ENSSSCG00000008889; Expressed in Ammon's horn and 12 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0001602; F:pancreatic polypeptide receptor activity; IBA:GO_Central.
DR GO; GO:0001601; F:peptide YY receptor activity; IBA:GO_Central.
DR GO; GO:0003214; P:cardiac left ventricle morphogenesis; IEA:Ensembl.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR CDD; cd15398; 7tmA_NPY5R; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000393; NPY5_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01016; NRPEPTIDEY5R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..446
FT /note="Neuropeptide Y receptor type 5"
FT /id="PRO_0000069941"
FT TOPO_DOM 1..42
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..407
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 429..446
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 297..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 442
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 446 AA; 50474 MW; B7F616C2394C6CA0 CRC64;
MGSEIPDYYN KTLASENNTV ATRNSGFPVW EDYKGSVDDL QYFLIGLYTF VSLLGFMGNL
LILMAVMRKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT SVLLDQWMFG KVMCHIMPFL
QCVTVLVSTL ILISIAIVRY HMIKHPVSNN LTANHGYFLI ATVWTLGLAI CSPLPVFHSL
VELQESFGSA WLSSRYLCVE SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRTISC
GLSSQDSKLE ENEMINLTLQ PAKRSGPQAK LSHHPKWTYS FIRRHRRRYS KKTACVRPAP
AGPALESREG RPPGKVGSMQ SQPPPSNKFM PGVPTCFEVK PEENSDVPEM RVSRSIMRLR
KRSRSVFYRL TVLILVFAVS WMPLHLFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL
NPILYGFLNN GIKADLMSLI HCLHVS
