NPY6R_HUMAN
ID NPY6R_HUMAN Reviewed; 290 AA.
AC Q99463; D3DQB4;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Putative neuropeptide Y receptor type 6;
DE Short=NPY6-R;
DE AltName: Full=NPY Y1-like receptor;
DE AltName: Full=Putative pancreatic polypeptide receptor 2;
DE Short=PP2;
GN Name=NPY6R; Synonyms=NPY1RL, Y2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Caudate nucleus;
RX PubMed=8910290; DOI=10.1074/jbc.271.44.27217;
RA Matsumoto M., Nomura T., Momose K., Ikeda Y., Kondou Y., Akiho H.,
RA Togami J., Kimura Y., Okada M., Yamaguchi T.;
RT "Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate
RT species.";
RL J. Biol. Chem. 271:27217-27220(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Heart;
RX PubMed=8910373; DOI=10.1074/jbc.271.44.27776;
RA Gregor P., Feng Y., Decarr L.B., Cornfield L.J., McCaleb M.L.;
RT "Molecular characterization of a second mouse pancreatic polypeptide
RT receptor and its inactivated human homologue.";
RL J. Biol. Chem. 271:27776-27781(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hypothalamus;
RX PubMed=9013614; DOI=10.1074/jbc.272.6.3622;
RA Rose P.M., Lynch J.S., Frazier S.T., Fisher S.M., Chung W., Battaglino P.,
RA Fathi Z., Leibel R., Fernandes P.;
RT "Molecular genetic analysis of a human neuropeptide Y receptor. The human
RT homolog of the murine 'Y5' receptor may be a pseudogene.";
RL J. Biol. Chem. 272:3622-3627(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: When expressed, is unable to bind pancreatic polypeptide
CC (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either
CC it is functionally inactive or that it may have acquired a pancreatic
CC polypeptide-independent function. {ECO:0000269|PubMed:8910290,
CC ECO:0000269|PubMed:8910373}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in heart, skeletal muscle,
CC gastrointestinal tissues, spleen, brain and adrenal glands.
CC {ECO:0000269|PubMed:8910290, ECO:0000269|PubMed:8910373}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Could be the product of a pseudogene. According to
CC PubMed:8910290, PubMed:8910373 and PubMed:9013614, the human NPY6R gene
CC is an expressed pseudogene containing a premature stop codon and
CC encoding a non-functional truncated protein missing the last
CC transmembrane domain. A single base pair deletion relative to the mouse
CC ortholog, results in a truncated protein lacking the seventh
CC transmembrane domain. {ECO:0000305}.
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DR EMBL; D86519; BAA13103.1; -; mRNA.
DR EMBL; U59431; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; U67780; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH471062; EAW62180.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW62181.1; -; Genomic_DNA.
DR AlphaFoldDB; Q99463; -.
DR SMR; Q99463; -.
DR IntAct; Q99463; 1.
DR GlyGen; Q99463; 2 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q99463; -.
DR PhosphoSitePlus; Q99463; -.
DR BioMuta; HGNC:7959; -.
DR DMDM; 74762699; -.
DR PRIDE; Q99463; -.
DR GeneCards; NPY6R; -.
DR HGNC; HGNC:7959; NPY6R.
DR MIM; 601770; gene.
DR neXtProt; NX_Q99463; -.
DR InParanoid; Q99463; -.
DR PhylomeDB; Q99463; -.
DR PathwayCommons; Q99463; -.
DR ChiTaRS; NPY6R; human.
DR Pharos; Q99463; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q99463; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000986; NeuroY6_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR PANTHER; PTHR24235:SF16; PTHR24235:SF16; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01017; NRPEPTIDEY6R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 5: Uncertain;
KW Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..290
FT /note="Putative neuropeptide Y receptor type 6"
FT /id="PRO_0000346130"
FT TOPO_DOM 1..39
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 109..196
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 154
FT /note="G -> S (in Ref. 2; U59431)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 290 AA; 33180 MW; 3ECCDD87001CA8DB CRC64;
MEVSLNHPAS NTTSTKNNNS AFFYFESCQP PSPALLLLCI AYTVVLIVGL FGNLSLIIII
FKKQRKAQNF TSILIANLSL SDTLVCVMCI HFTIIYTLMD HWIFGDTMCR LTSYVQSVSI
SVSIFSLVFT AVERYQLIVN PRGWKPSVTH AYWGITLIWL FSLLLSIPFF LSYHLTDEPF
RNLSLPTDLY THQVACVENW PSKKDRLLFT TSLFLLQYFV PLGFILICYL KIVICLRRRN
AKVDKKKENE GRLNENKRIN TMLISIVVTF GACWLPRISS MSSLTGIMRC
