NPY6R_MOUSE
ID NPY6R_MOUSE Reviewed; 371 AA.
AC Q61212; Q3ZAW3;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Neuropeptide Y receptor type 6;
DE Short=NPY6-R;
DE AltName: Full=Pancreatic polypeptide receptor 2;
DE Short=PP2;
GN Name=Npy6r; Synonyms=Npy5r, Ppyr2, Y2b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129;
RX PubMed=8663568; DOI=10.1074/jbc.271.28.16435;
RA Weinberg D.H., Sirinathsinghji D.J.S., Tan C.P., Shiao L.-L., Morin N.,
RA Rigby M.R., Heavens R.H., Rapoport D.R., Bayne M.L., Cascieri M.A.,
RA Strader C.D., Linemeyer D.L., Macneil D.J.;
RT "Cloning and expression of a novel neuropeptide Y receptor.";
RL J. Biol. Chem. 271:16435-16438(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=129/Sv;
RX PubMed=8910373; DOI=10.1074/jbc.271.44.27776;
RA Gregor P., Feng Y., Decarr L.B., Cornfield L.J., McCaleb M.L.;
RT "Molecular characterization of a second mouse pancreatic polypeptide
RT receptor and its inactivated human homologue.";
RL J. Biol. Chem. 271:27776-27781(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank order of
CC affinity of this receptor for pancreatic polypeptides is NPY = PYY >=
CC NPY (2-36) = [Leu-31, Pro-34] NPY > NPY (13-36) > PP. The activity of
CC this receptor is mediated by G proteins that inhibits adenylate cyclase
CC activity.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Kidney and discrete regions of the hypothalamus
CC including the suprachiasmatic nucleus, anterior hypothalamus, bed
CC nucleus stria terminalis, and the ventromedial nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryo at 7 dpc.
CC {ECO:0000269|PubMed:8910373}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Was originally called NPY5-R. {ECO:0000305}.
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DR EMBL; U58367; AAB18624.1; -; Genomic_DNA.
DR EMBL; U59430; AAB19188.1; -; Genomic_DNA.
DR EMBL; AK030279; BAC26875.1; -; mRNA.
DR EMBL; BC103620; AAI03621.1; -; mRNA.
DR EMBL; BC103621; AAI03622.1; -; mRNA.
DR EMBL; BC103622; AAI03623.1; -; mRNA.
DR EMBL; BC103667; AAI03668.1; -; mRNA.
DR CCDS; CCDS29227.1; -.
DR RefSeq; NP_035065.1; NM_010935.3.
DR AlphaFoldDB; Q61212; -.
DR SMR; Q61212; -.
DR STRING; 10090.ENSMUSP00000040797; -.
DR GlyGen; Q61212; 3 sites.
DR PhosphoSitePlus; Q61212; -.
DR PaxDb; Q61212; -.
DR PRIDE; Q61212; -.
DR ProteomicsDB; 293886; -.
DR DNASU; 18169; -.
DR Ensembl; ENSMUST00000042747; ENSMUSP00000040797; ENSMUSG00000038071.
DR GeneID; 18169; -.
DR KEGG; mmu:18169; -.
DR UCSC; uc008euv.1; mouse.
DR CTD; 4888; -.
DR MGI; MGI:1098590; Npy6r.
DR VEuPathDB; HostDB:ENSMUSG00000038071; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000163511; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; Q61212; -.
DR OMA; FNVVFDW; -.
DR OrthoDB; 609835at2759; -.
DR PhylomeDB; Q61212; -.
DR TreeFam; TF315303; -.
DR BioGRID-ORCS; 18169; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q61212; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q61212; protein.
DR Bgee; ENSMUSG00000038071; Expressed in seminal vesicle and 19 other tissues.
DR Genevisible; Q61212; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IDA:MGI.
DR GO; GO:0001601; F:peptide YY receptor activity; IDA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000986; NeuroY6_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR PANTHER; PTHR24235:SF16; PTHR24235:SF16; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01017; NRPEPTIDEY6R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..371
FT /note="Neuropeptide Y receptor type 6"
FT /id="PRO_0000069943"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..297
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..371
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 336
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 109..196
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 371 AA; 42714 MW; E4AABB987CEB74B7 CRC64;
MEVLTNQPTP NKTSGKSNNS AFFYFESCQP PFLAILLLLI AYTVILIMGI FGNLSLIIII
FKKQREAQNV TNILIANLSL SDILVCVMCI PFTVIYTLMD HWVFGNTMCK LTSYVQSVSV
SVSIFSLVLI AIERYQLIVN PRGWKPRVAH AYWGIILIWL ISLTLSIPLF LSYHLTNEPF
HNLSLPTDIY THQVACVEIW PSKLNQLLFS TSLFMLQYFV PLGFILICYL KIVLCLRKRT
RQVDRRKENK SRLNENKRVN VMLISIVVTF GACWLPLNIF NVIFDWYHEM LMSCHHDLVF
VVCHLIAMVS TCINPLFYGF LNKNFQKDLM MLIHHCWCGE PQESYENIAM STMHTDESKG
SLKLAHIPTG I
