ID   NPY6R_RABIT             Reviewed;         371 AA.
AC   P79217;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Neuropeptide Y receptor type 6;
DE            Short=NPY6-R;
GN   Name=NPY6R; Synonyms=Y2B;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   STRAIN=Japanese white; TISSUE=Skeletal muscle;
RX   PubMed=8910290; DOI=10.1074/jbc.271.44.27217;
RA   Matsumoto M., Nomura T., Momose K., Ikeda Y., Kondou Y., Akiho H.,
RA   Togami J., Kimura Y., Okada M., Yamaguchi T.;
RT   "Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate
RT   species.";
RL   J. Biol. Chem. 271:27217-27220(1996).
CC   -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity of
CC       this receptor is mediated by G proteins that inhibit adenylate cyclase
CC       activity. {ECO:0000269|PubMed:8910290}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in hippocampus, striatum, hypothalamus,
CC       cerebellum, small intestine, colon and adrenal gland.
CC       {ECO:0000269|PubMed:8910290}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; D86521; BAA13104.1; -; mRNA.
DR   RefSeq; NP_001076242.1; NM_001082773.1.
DR   RefSeq; XP_008253087.1; XM_008254865.1.
DR   RefSeq; XP_017196474.1; XM_017340985.1.
DR   AlphaFoldDB; P79217; -.
DR   SMR; P79217; -.
DR   STRING; 9986.ENSOCUP00000023630; -.
DR   Ensembl; ENSOCUT00000011236; ENSOCUP00000023630; ENSOCUG00000011240.
DR   GeneID; 100009561; -.
DR   KEGG; ocu:100009561; -.
DR   CTD; 4888; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000163511; -.
DR   HOGENOM; CLU_009579_6_1_1; -.
DR   InParanoid; P79217; -.
DR   OMA; FNVVFDW; -.
DR   OrthoDB; 609835at2759; -.
DR   TreeFam; TF315303; -.
DR   Proteomes; UP000001811; Chromosome 3.
DR   Bgee; ENSOCUG00000011240; Expressed in testis.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000986; NeuroY6_rcpt.
DR   InterPro; IPR000611; NPY_rcpt.
DR   PANTHER; PTHR24235:SF16; PTHR24235:SF16; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01017; NRPEPTIDEY6R.
DR   PRINTS; PR01012; NRPEPTIDEYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..371
FT                   /note="Neuropeptide Y receptor type 6"
FT                   /id="PRO_0000069944"
FT   TOPO_DOM        1..31
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..72
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..111
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..150
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..213
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..263
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..297
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        319..371
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   LIPID           336
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        11
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        182
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        109..196
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   371 AA;  42447 MW;  5847E358EE320F24 CRC64;
     MEVSLNDPAS NKTSAKSNSS AFFYFESCQS PSLALLLLLI AYTVVLIMGI CGNLSLITII
     FKKQREAQNV TNILIANLSL SDILVCVMCI PFTAIYTLMD RWIFGNTMCK LTSYVQSVSI
     SVSIFSLVLI AIERYQLIVN PRGWKPSASH AYWGIMLIWL FSLLLSIPLL LSYHLTDEPF
     RNLSLPTDLY SHHVVCVEHW PSKTNQLLYS TSLIMLQYFV PLGFMFICYL KIVICLHKRN
     SKIDRRRENE SRLTENKRIN TMLISIVVTF AACWLPLNTF NVIFDWYHEV LMSCHHDLVF
     AICHLVAMVS TCINPLFYGF LNRNFQKDLV VLIHHCLCFA LRERYENIAI STLHTDESKG
     SLRVAHIPAG I