ID   NPYV_MEIAT              Reviewed;          99 AA.
AC   P0DP55;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Pro-neuropeptide Y;
DE   Contains:
DE     RecName: Full=Neuropeptide Y {ECO:0000303|PubMed:28366739};
DE              Short=NPY;
DE   Contains:
DE     RecName: Full=C-flanking peptide of NPY {ECO:0000305};
DE   Flags: Precursor;
OS   Meiacanthus atrodorsalis (Forktail blenny) (Petroscirtes atrodorsalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Blenniimorphae; Blenniiformes; Blennioidei; Blenniidae;
OC   Blenniinae; Meiacanthus.
OX   NCBI_TaxID=1405650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Venom gland;
RX   PubMed=28366739; DOI=10.1016/j.cub.2017.02.067;
RA   Casewell N.R., Visser J.C., Baumann K., Dobson J., Han H., Kuruppu S.,
RA   Morgan M., Romilio A., Weisbecker V., Ali S.A., Debono J., Koludarov I.,
RA   Que I., Bird G.C., Cooke G.M., Nouwens A., Hodgson W.C., Wagstaff S.C.,
RA   Cheney K.L., Vetter I., van der Weerd L., Richardson M.K., Fry B.G.;
RT   "The evolution of fangs, venom, and mimicry systems in blenny fishes.";
RL   Curr. Biol. 27:1184-1191(2017).
CC   -!- FUNCTION: Neuropeptides Y are crucial for the regulation of
CC       cardiovascular processes such as blood pressure. Venom of Meiacanthus
CC       fangblennies shows a potent hypotensive bioactivity (tested on
CC       M.grammistes), but has no effect on the heart rate. Therefore, finding
CC       a neuropeptide Y sequence in M.atrodorsalis venom suggests that this
CC       protein act as a hypotensive agent (Probable).
CC       {ECO:0000305|PubMed:28366739}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:28366739}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. Heavily expressed in
CC       the venom gland transcriptome. {ECO:0000269|PubMed:28366739}.
CC   -!- MISCELLANEOUS: In contrast to venom of most venomous species, the venom
CC       of Meiacanthus fangblennies is relatively painless, when tested on
CC       mammals. While species-specific nociceptive effects are possible, this
CC       defensive venom is surprisingly multifunctional, being markedly
CC       hypotensive (via neuropeptide Y and/ or enkephalins), weakly neurotoxic
CC       (unknown components, possibly PLA2s), and perhaps also pro-inflammatory
CC       (PLA2s and/or enkephalins). The pronounced hypotensive effects induced
CC       by venom peptides seem highly likely to affect the coordination and/or
CC       swim performance of envenomed fishes and therefore likely confer a
CC       fitness advantage to the fangblenny by facilitating escape from
CC       predators. {ECO:0000269|PubMed:28366739}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   AlphaFoldDB; P0DP55; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hypotensive agent;
KW   Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         29..64
FT                   /note="Neuropeptide Y"
FT                   /evidence="ECO:0000250|UniProtKB:P01304"
FT                   /id="PRO_0000440265"
FT   PEPTIDE         68..99
FT                   /note="C-flanking peptide of NPY"
FT                   /id="PRO_0000440266"
FT   MOD_RES         64
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P01304"
SQ   SEQUENCE   99 AA;  11340 MW;  5189DA60E95360C8 CRC64;
     MHPNYVSWLG AVGFLLWALL CLGAWTEAYP VKPENPGEDA PAEELAKYYS ALRHYINLIT
     RQRYGKRSTP EILDTLVSEL LLKETSDTLP QSRYDPSLW