NPY_ALLMI
ID NPY_ALLMI Reviewed; 36 AA.
AC P68007; P09640;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=Neuropeptide Y;
DE Short=NPY;
GN Name=NPY;
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Brain;
RX PubMed=8101369; DOI=10.1016/0196-9781(93)90147-9;
RA Wang Y., Conlon J.M.;
RT "Neuroendocrine peptides (NPY, GRP, VIP, somatostatin) from the brain and
RT stomach of the alligator.";
RL Peptides 14:573-579(1993).
RN [2]
RP PROTEIN SEQUENCE, AND AMIDATION AT TYR-36.
RC TISSUE=Brain;
RX PubMed=8351403; DOI=10.1016/0167-0115(93)90364-e;
RA Parker D.B., McRory J.E., Fischer W.H., Park M., Sherwood N.M.;
RT "Primary structure of neuropeptide Y from brains of the American alligator
RT (Alligator mississippiensis).";
RL Regul. Pept. 45:379-386(1993).
CC -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC of gonadotrophin-release hormone. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; P68007; -.
DR SMR; P68007; -.
DR STRING; 8496.XP_006263006.1; -.
DR eggNOG; ENOG502S2BU; Eukaryota.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00126; PAH; 1.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR PANTHER; PTHR10533; PTHR10533; 1.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT PEPTIDE 1..36
FT /note="Neuropeptide Y"
FT /id="PRO_0000044789"
FT MOD_RES 36
FT /note="Tyrosine amide"
FT /evidence="ECO:0000269|PubMed:8351403"
SQ SEQUENCE 36 AA; 4273 MW; 0D06921202CD0DD6 CRC64;
YPSKPDNPGE DAPAEDMARY YSALRHYINL ITRQRY