ID   NPY_APLCA               Reviewed;          92 AA.
AC   Q27441;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Pro-neuropeptide Y;
DE   Contains:
DE     RecName: Full=Neuropeptide Y;
DE     AltName: Full=Neuropeptide tyrosine;
DE              Short=NPY;
DE   Contains:
DE     RecName: Full=C-flanking peptide of NPY;
DE              Short=CPON;
DE   Flags: Precursor;
GN   Name=NPY;
OS   Aplysia californica (California sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=6500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-61, AMIDATION AT PHE-61,
RP   FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=CNS;
RX   PubMed=1524828; DOI=10.1016/0896-6273(92)90188-j;
RA   Rajpara S.M., Garcia P.D., Roberts R., Eliassen J.C., Owens D.F.,
RA   Maltby D., Myers R.M., Mayeri E.;
RT   "Identification and molecular cloning of a neuropeptide Y homolog that
RT   produces prolonged inhibition in Aplysia neurons.";
RL   Neuron 9:505-513(1992).
CC   -!- FUNCTION: May play a role in the regulation of viscermotor functions
CC       during egg laying. {ECO:0000269|PubMed:1524828}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the abdominal ganglion, to
CC       lesser extent in the pleural-pedal ganglion and much lower in the
CC       cerebral ganglion. {ECO:0000269|PubMed:1524828}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; M98854; AAA27772.1; -; mRNA.
DR   PIR; JH0716; JH0716.
DR   RefSeq; NP_001191635.1; NM_001204706.1.
DR   AlphaFoldDB; Q27441; -.
DR   SMR; Q27441; -.
DR   GeneID; 100533423; -.
DR   OrthoDB; 1606795at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   Pfam; PF00159; Hormone_3; 1.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:1524828"
FT   PEPTIDE         22..61
FT                   /note="Neuropeptide Y"
FT                   /id="PRO_0000260455"
FT   PEPTIDE         62..92
FT                   /note="C-flanking peptide of NPY"
FT                   /id="PRO_0000260456"
FT   MOD_RES         61
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:1524828"
SQ   SEQUENCE   92 AA;  10720 MW;  FB3BC98C6054216E CRC64;
     MQRVILVVLL LSCMAVLSVR ADNSEMLAPP PRPEEFTSAQ QLRQYLAALN EYYSIMGRPR
     FGKRGDSFRK REFFRTNGER YPEDAAAWTE FQ