ID   NPY_BOVIN               Reviewed;          97 AA.
AC   Q6RUW3; A2VDW2;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Pro-neuropeptide Y;
DE   Contains:
DE     RecName: Full=Neuropeptide Y;
DE     AltName: Full=Neuropeptide tyrosine;
DE              Short=NPY;
DE   Contains:
DE     RecName: Full=C-flanking peptide of NPY;
DE              Short=CPON;
DE   Flags: Precursor;
GN   Name=NPY;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15147401; DOI=10.1111/j.1365-2052.2004.01116.x;
RA   Thue T.D., Buchanan F.C.;
RT   "Linkage mapping of NPY to bovine chromosome 4.";
RL   Anim. Genet. 35:245-246(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC       of gonadotrophin-release hormone. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic vesicle, secretory vesicle,
CC       neuronal dense core vesicle {ECO:0000250|UniProtKB:P07808}.
CC   -!- PTM: The neuropeptide Y form is cleaved at Pro-30 by the prolyl
CC       endopeptidase FAP (seprase) activity (in vitro).
CC       {ECO:0000250|UniProtKB:P01303}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; AY491054; AAR37328.1; -; Genomic_DNA.
DR   EMBL; BC133432; AAI33433.1; -; mRNA.
DR   RefSeq; NP_001014845.1; NM_001014845.3.
DR   RefSeq; XP_010802617.1; XM_010804315.2.
DR   RefSeq; XP_010802618.1; XM_010804316.2.
DR   AlphaFoldDB; Q6RUW3; -.
DR   STRING; 9913.ENSBTAP00000005903; -.
DR   PaxDb; Q6RUW3; -.
DR   Ensembl; ENSBTAT00000005903; ENSBTAP00000005903; ENSBTAG00000004503.
DR   Ensembl; ENSBTAT00000081425; ENSBTAP00000066814; ENSBTAG00000004503.
DR   Ensembl; ENSBTAT00000083633; ENSBTAP00000061725; ENSBTAG00000004503.
DR   GeneID; 504216; -.
DR   KEGG; bta:504216; -.
DR   CTD; 4852; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004503; -.
DR   VGNC; VGNC:32222; NPY.
DR   eggNOG; ENOG502S2BU; Eukaryota.
DR   GeneTree; ENSGT00940000156475; -.
DR   HOGENOM; CLU_162379_1_0_1; -.
DR   InParanoid; Q6RUW3; -.
DR   OMA; QGTMRLW; -.
DR   OrthoDB; 1542445at2759; -.
DR   TreeFam; TF332778; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000004503; Expressed in pigment epithelium of eye and 62 other tissues.
DR   ExpressionAtlas; Q6RUW3; baseline.
DR   GO; GO:0005615; C:extracellular space; ISS:HGNC-UCL.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0098992; C:neuronal dense core vesicle; ISS:UniProtKB.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
DR   GO; GO:0008343; P:adult feeding behavior; ISS:HGNC-UCL.
DR   GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
DR   GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0032100; P:positive regulation of appetite; ISS:HGNC-UCL.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Cytoplasmic vesicle;
KW   Neuropeptide; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         29..64
FT                   /note="Neuropeptide Y"
FT                   /id="PRO_0000234088"
FT   PEPTIDE         68..97
FT                   /note="C-flanking peptide of NPY"
FT                   /id="PRO_0000234089"
FT   SITE            30..31
FT                   /note="Cleavage; by FAP"
FT                   /evidence="ECO:0000250|UniProtKB:P01303"
FT   MOD_RES         64
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         83
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P01303"
SQ   SEQUENCE   97 AA;  10764 MW;  6C2209A260CF8482 CRC64;
     MLGSKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDLARYYS ALRHYINLIT
     RQRYGKRSSP ETLISDLLMR ESTGNIPRTR LEDPSMW