NPY_CHICK
ID NPY_CHICK Reviewed; 97 AA.
AC P28673;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Pro-neuropeptide Y;
DE Contains:
DE RecName: Full=Neuropeptide Y;
DE AltName: Full=Neuropeptide tyrosine;
DE Short=NPY;
DE Contains:
DE RecName: Full=C-flanking peptide of NPY;
DE Short=CPON;
DE Flags: Precursor;
GN Name=NPY;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Brain;
RX PubMed=1549597; DOI=10.1073/pnas.89.6.2350;
RA Blomqvist A.G., Soederberg C., Lundell I., Milner R.J., Larhammar D.;
RT "Strong evolutionary conservation of neuropeptide Y: sequences of chicken,
RT goldfish, and Torpedo marmorata DNA clones.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:2350-2354(1992).
CC -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC of gonadotrophin-release hormone.
CC -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic vesicle, secretory vesicle,
CC neuronal dense core vesicle {ECO:0000250|UniProtKB:P07808}.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M87294; AAA48991.1; -; mRNA.
DR EMBL; M87295; AAA48992.1; -; Genomic_DNA.
DR EMBL; M87298; AAA48992.1; JOINED; Genomic_DNA.
DR PIR; A41979; A41979.
DR RefSeq; NP_990804.1; NM_205473.1.
DR AlphaFoldDB; P28673; -.
DR STRING; 9031.ENSGALP00000017870; -.
DR PaxDb; P28673; -.
DR Ensembl; ENSGALT00000017891; ENSGALP00000017870; ENSGALG00000010983.
DR GeneID; 396464; -.
DR KEGG; gga:396464; -.
DR CTD; 4852; -.
DR VEuPathDB; HostDB:geneid_396464; -.
DR eggNOG; ENOG502S2BU; Eukaryota.
DR GeneTree; ENSGT00940000156475; -.
DR HOGENOM; CLU_162379_1_0_1; -.
DR InParanoid; P28673; -.
DR OMA; QGTMRLW; -.
DR OrthoDB; 1542445at2759; -.
DR PhylomeDB; P28673; -.
DR TreeFam; TF332778; -.
DR Reactome; R-GGA-375276; Peptide ligand-binding receptors.
DR Reactome; R-GGA-418594; G alpha (i) signalling events.
DR PRO; PR:P28673; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000010983; Expressed in brain and 11 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0098992; C:neuronal dense core vesicle; ISS:UniProtKB.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
DR GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR CDD; cd00126; PAH; 1.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR PANTHER; PTHR10533; PTHR10533; 1.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Cytoplasmic vesicle;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000250"
FT PEPTIDE 29..64
FT /note="Neuropeptide Y"
FT /id="PRO_0000025333"
FT PEPTIDE 68..97
FT /note="C-flanking peptide of NPY"
FT /id="PRO_0000025334"
FT MOD_RES 64
FT /note="Tyrosine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 97 AA; 11097 MW; 9C924B0E2D9B27CB CRC64;
MQGTMRLWVS VLTFALSLLI CLGTLAEAYP SKPDSPGEDA PAEDMARYYS ALRHYINLIT
RQRYGKRSSP ETLISDLLLR ESTENIPRSR FEDPSMW
