ID   NPY_DANRE               Reviewed;          96 AA.
AC   Q9I8P3;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Pro-neuropeptide Y;
DE   Contains:
DE     RecName: Full=Neuropeptide Y;
DE     AltName: Full=Neuropeptide tyrosine;
DE              Short=NPY;
DE   Contains:
DE     RecName: Full=C-flanking peptide of NPY;
DE              Short=CPON;
DE   Flags: Precursor;
GN   Name=npy;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10936170; DOI=10.1046/j.1471-4159.2000.0750908.x;
RA   Soederberg C., Wraith A., Ringvall M., Yan Y.-L., Postlethwait J.H.,
RA   Brodin L., Larhammar D.;
RT   "Zebrafish genes for neuropeptide Y and peptide YY reveal origin by
RT   chromosome duplication from an ancestral gene linked to the homeobox
RT   cluster.";
RL   J. Neurochem. 75:908-918(2000).
CC   -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC       of gonadotrophin-release hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; AF233874; AAF79941.1; -; Genomic_DNA.
DR   RefSeq; NP_571149.1; NM_131074.2.
DR   AlphaFoldDB; Q9I8P3; -.
DR   STRING; 7955.ENSDARP00000052619; -.
DR   PaxDb; Q9I8P3; -.
DR   Ensembl; ENSDART00000052620; ENSDARP00000052619; ENSDARG00000036222.
DR   Ensembl; ENSDART00000188813; ENSDARP00000157094; ENSDARG00000036222.
DR   GeneID; 30281; -.
DR   KEGG; dre:30281; -.
DR   CTD; 4852; -.
DR   ZFIN; ZDB-GENE-980526-438; npy.
DR   eggNOG; ENOG502S2BU; Eukaryota.
DR   GeneTree; ENSGT00940000156475; -.
DR   HOGENOM; CLU_162379_1_0_1; -.
DR   InParanoid; Q9I8P3; -.
DR   OMA; QGTMRLW; -.
DR   OrthoDB; 1542445at2759; -.
DR   PhylomeDB; Q9I8P3; -.
DR   TreeFam; TF332778; -.
DR   Reactome; R-DRE-375276; Peptide ligand-binding receptors.
DR   Reactome; R-DRE-418594; G alpha (i) signalling events.
DR   PRO; PR:Q9I8P3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000036222; Expressed in brain and 17 other tissues.
DR   ExpressionAtlas; Q9I8P3; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0031841; F:neuropeptide Y receptor binding; IDA:ZFIN.
DR   GO; GO:0031843; F:type 2 neuropeptide Y receptor binding; IDA:ZFIN.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0071878; P:negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; IMP:ZFIN.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0045938; P:positive regulation of circadian sleep/wake cycle, sleep; IMP:ZFIN.
DR   GO; GO:2000253; P:positive regulation of feeding behavior; IMP:ZFIN.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         29..64
FT                   /note="Neuropeptide Y"
FT                   /id="PRO_0000025335"
FT   PEPTIDE         68..96
FT                   /note="C-flanking peptide of NPY"
FT                   /id="PRO_0000025336"
FT   MOD_RES         64
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   96 AA;  11032 MW;  4D82A025C8151E33 CRC64;
     MNPNMKMWMS WAACAFLLFV CLGTLTEGYP TKPDNPGEDA PAEELAKYYS ALRHYINLIT
     RQRYGKRSSA DTLISDLLIG ETESRPQTRY EDHLAW