NPY_GADMO
ID NPY_GADMO Reviewed; 36 AA.
AC P80167;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Neuropeptide Y;
DE Short=NPY;
GN Name=npy;
OS Gadus morhua (Atlantic cod).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus.
OX NCBI_TaxID=8049;
RN [1]
RP PROTEIN SEQUENCE, AND AMIDATION AT TYR-36.
RC TISSUE=Brain;
RX PubMed=1459125; DOI=10.1111/j.1432-1033.1992.tb17435.x;
RA Jensen J., Conlon J.M.;
RT "Characterization of peptides related to neuropeptide tyrosine and peptide
RT tyrosine-tyrosine from the brain and gastrointestinal tract of teleost
RT fish.";
RL Eur. J. Biochem. 210:405-410(1992).
CC -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC of gonadotrophin-release hormone.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR PIR; S27054; S27054.
DR AlphaFoldDB; P80167; -.
DR SMR; P80167; -.
DR STRING; 8049.ENSGMOP00000014649; -.
DR Proteomes; UP000694546; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00126; PAH; 1.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR PANTHER; PTHR10533; PTHR10533; 1.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide; Reference proteome;
KW Secreted.
FT PEPTIDE 1..36
FT /note="Neuropeptide Y"
FT /id="PRO_0000044790"
FT MOD_RES 36
FT /note="Tyrosine amide"
FT /evidence="ECO:0000269|PubMed:1459125"
SQ SEQUENCE 36 AA; 4267 MW; 17B09AA83867A7B6 CRC64;
YPIKPENPGE DAPADELAKY YSALRHYINL ITRQRY