ID   NPY_LAMFL               Reviewed;         104 AA.
AC   P48097;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Neuropeptide Y;
DE            Short=NPY;
DE   Flags: Precursor;
GN   Name=npy;
OS   Lampetra fluviatilis (European river lamprey) (Petromyzon fluviatilis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Lampetra.
OX   NCBI_TaxID=7748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain, and Spinal cord;
RX   PubMed=8028041; DOI=10.1002/jnr.490370510;
RA   Soederberg C., Pieribone V.A., Dahlstrand J., Brodin L., Larhammar D.;
RT   "Neuropeptide role of both peptide YY and neuropeptide Y in vertebrates
RT   suggested by abundant expression of their mRNAs in a cyclostome brain.";
RL   J. Neurosci. Res. 37:633-640(1994).
CC   -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC       of gonadotrophin-release hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Lateral brainstem, dorsal spinal cord and retina.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; L22867; AAA21352.1; -; mRNA.
DR   PIR; I50808; I50808.
DR   AlphaFoldDB; P48097; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide; Secreted;
KW   Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         35..70
FT                   /note="Neuropeptide Y"
FT                   /id="PRO_0000025345"
FT   PROPEP          74..104
FT                   /note="C-terminal extension"
FT                   /id="PRO_0000025346"
FT   MOD_RES         70
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   104 AA;  11620 MW;  B02B6AE07DFE73BA CRC64;
     MMSCFAGTRG SARVWLCAIA LCLLASSCAR GAAAFPNKPD SPGEDAPAED LARYLSAVRH
     YINLITRQRY GKRTLTEPYV PEFIFQENRG DRSSNPRFDS VTMW