ID   NPY_MACMU               Reviewed;          97 AA.
AC   Q9XSW6;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Pro-neuropeptide Y;
DE   Contains:
DE     RecName: Full=Neuropeptide Y;
DE     AltName: Full=Neuropeptide tyrosine;
DE              Short=NPY;
DE   Contains:
DE     RecName: Full=C-flanking peptide of NPY;
DE              Short=CPON;
DE   Flags: Precursor;
GN   Name=NPY;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Abler L.A., Golos T.G., Terasawa E.;
RT   "Developmental changes in NPY mRNA expression in female rhesus monkeys.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 29-38 IN COMPLEX WITH DPP4.
RX   PubMed=14718659; DOI=10.1110/ps.03460604;
RA   Aertgeerts K., Ye S., Tennant M.G., Kraus M.L., Rogers J., Sang B.-C.,
RA   Skene R.J., Webb D.R., Prasad G.S.;
RT   "Crystal structure of human dipeptidyl peptidase IV in complex with a
RT   decapeptide reveals details on substrate specificity and tetrahedral
RT   intermediate formation.";
RL   Protein Sci. 13:412-421(2004).
CC   -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC       of gonadotrophin-release hormone. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic vesicle, secretory vesicle,
CC       neuronal dense core vesicle {ECO:0000250|UniProtKB:P07808}.
CC   -!- PTM: The neuropeptide Y form is cleaved at Pro-30 by the prolyl
CC       endopeptidase FAP (seprase) activity (in vitro).
CC       {ECO:0000250|UniProtKB:P01303}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; AF162280; AAD43583.1; -; mRNA.
DR   RefSeq; NP_001027986.1; NM_001032814.1.
DR   PDB; 1R9N; X-ray; 2.30 A; E/F/G/H=29-38.
DR   PDBsum; 1R9N; -.
DR   AlphaFoldDB; Q9XSW6; -.
DR   SMR; Q9XSW6; -.
DR   STRING; 9544.ENSMMUP00000012853; -.
DR   Ensembl; ENSMMUT00000071340; ENSMMUP00000051181; ENSMMUG00000009818.
DR   GeneID; 574114; -.
DR   KEGG; mcc:574114; -.
DR   CTD; 4852; -.
DR   VEuPathDB; HostDB:ENSMMUG00000009818; -.
DR   VGNC; VGNC:75393; NPY.
DR   eggNOG; ENOG502S2BU; Eukaryota.
DR   GeneTree; ENSGT00940000156475; -.
DR   HOGENOM; CLU_162379_1_0_1; -.
DR   InParanoid; Q9XSW6; -.
DR   OMA; QGTMRLW; -.
DR   OrthoDB; 1542445at2759; -.
DR   TreeFam; TF332778; -.
DR   EvolutionaryTrace; Q9XSW6; -.
DR   Proteomes; UP000006718; Chromosome 3.
DR   Bgee; ENSMMUG00000009818; Expressed in Ammon's horn and 13 other tissues.
DR   ExpressionAtlas; Q9XSW6; baseline.
DR   GO; GO:0005615; C:extracellular space; ISS:HGNC-UCL.
DR   GO; GO:0098992; C:neuronal dense core vesicle; ISS:UniProtKB.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
DR   GO; GO:0008343; P:adult feeding behavior; ISS:HGNC-UCL.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0032100; P:positive regulation of appetite; ISS:HGNC-UCL.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Cleavage on pair of basic residues;
KW   Cytoplasmic vesicle; Neuropeptide; Phosphoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         29..64
FT                   /note="Neuropeptide Y"
FT                   /id="PRO_0000025323"
FT   PEPTIDE         68..97
FT                   /note="C-flanking peptide of NPY"
FT                   /id="PRO_0000025324"
FT   SITE            30..31
FT                   /note="Cleavage; by FAP"
FT                   /evidence="ECO:0000250|UniProtKB:P01303"
FT   MOD_RES         64
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P01303"
FT   MOD_RES         83
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P01303"
SQ   SEQUENCE   97 AA;  10840 MW;  2D2209BAC20BD5EE CRC64;
     MLGSKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS ALRHYINLIT
     RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPSMW