ID   NPY_PAROL               Reviewed;          99 AA.
AC   Q90WF4;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Pro-neuropeptide Y;
DE   Contains:
DE     RecName: Full=Neuropeptide Y;
DE     AltName: Full=Neuropeptide tyrosine;
DE              Short=NPY;
DE   Contains:
DE     RecName: Full=C-flanking peptide of NPY;
DE              Short=CPON;
DE   Flags: Precursor;
GN   Name=npy;
OS   Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Paralichthyidae;
OC   Paralichthys.
OX   NCBI_TaxID=8255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=11944964; DOI=10.1006/gcen.2001.7774;
RA   Kurokawa T., Suzuki T.;
RT   "Development of neuropeptide Y-related peptides in the digestive organs
RT   during the larval stage of Japanese flounder, Paralichthys olivaceus.";
RL   Gen. Comp. Endocrinol. 126:30-38(2002).
CC   -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC       of gonadotrophin-release hormone. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; AB055211; BAB62409.1; -; mRNA.
DR   AlphaFoldDB; Q90WF4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide; Secreted;
KW   Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         29..64
FT                   /note="Neuropeptide Y"
FT                   /id="PRO_0000025347"
FT   PEPTIDE         68..99
FT                   /note="C-flanking peptide of NPY"
FT                   /id="PRO_0000025348"
FT   MOD_RES         64
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   99 AA;  11215 MW;  6FEED47F24CF6498 CRC64;
     MHPNLVSWLG TLGLLLWALL CLSALTEGYP VKPENPGDDA PAEELAKYYS ALRHYINLIT
     RQRYGKRSSP EILDTLVSEL LLKESTDTLP QSRYDPSLW