ID   NPY_RABIT               Reviewed;          36 AA.
AC   P68006; P09640;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Neuropeptide Y;
DE            Short=NPY;
GN   Name=NPY;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT TYR-36.
RX   PubMed=3368580; DOI=10.1016/0167-0115(88)90064-x;
RA   O'Hare M.M.T., Tenmoku S., Aakerlund L., Hilsted L., Johnsen A.,
RA   Schwartz T.W.;
RT   "Neuropeptide Y in guinea pig, rabbit, rat and man. Identical amino acid
RT   sequence and oxidation of methionine-17.";
RL   Regul. Pept. 20:293-304(1988).
CC   -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC       of gonadotrophin-release hormone. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic vesicle, secretory vesicle,
CC       neuronal dense core vesicle {ECO:0000250|UniProtKB:P07808}.
CC   -!- TISSUE SPECIFICITY: One of the most abundant peptides in the nervous
CC       system. Also found in some chromaffin cells of the adrenal medulla.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A30485; A30485.
DR   AlphaFoldDB; P68006; -.
DR   SMR; P68006; -.
DR   STRING; 9986.ENSOCUP00000009261; -.
DR   eggNOG; ENOG502S2BU; Eukaryota.
DR   InParanoid; P68006; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0098992; C:neuronal dense core vesicle; ISS:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cytoplasmic vesicle; Direct protein sequencing; Neuropeptide;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Neuropeptide Y"
FT                   /evidence="ECO:0000269|PubMed:3368580"
FT                   /id="PRO_0000044788"
FT   MOD_RES         36
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:3368580"
SQ   SEQUENCE   36 AA;  4273 MW;  0D06921202CD0DD6 CRC64;
     YPSKPDNPGE DAPAEDMARY YSALRHYINL ITRQRY