ID   NPY_RANTE               Reviewed;          36 AA.
AC   P69102; P29949;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Melanostatin;
DE   AltName: Full=Melanotropin release-inhibiting factor;
DE   AltName: Full=Neuropeptide Y;
DE            Short=NPY;
OS   Rana temporaria (European common frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=8407;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT TYR-36.
RC   TISSUE=Brain;
RX   PubMed=1539111; DOI=10.1016/0167-0115(92)90663-f;
RA   McKay D.M., Shaw C., Halton D.W., Thim L., Buchanan K.D.;
RT   "The primary structure and tissue distribution of an amphibian neuropeptide
RT   Y.";
RL   Regul. Pept. 37:143-153(1992).
CC   -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC       of gonadotrophin-release hormone. NPY may play a physiological role in
CC       the regulation of pituitary melanotrophs.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   PIR; A48540; A48540.
DR   AlphaFoldDB; P69102; -.
DR   SMR; P69102; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Melanostatin"
FT                   /id="PRO_0000044793"
FT   MOD_RES         36
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:1539111"
SQ   SEQUENCE   36 AA;  4245 MW;  0D1425E202CD0DD6 CRC64;
     YPSKPDNPGE DAPAEDMAKY YSALRHYINL ITRQRY