ID   NPY_SHEEP               Reviewed;          97 AA.
AC   P14765; Q8SPF7; Q9TSI6;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2003, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Pro-neuropeptide Y;
DE   Contains:
DE     RecName: Full=Neuropeptide Y;
DE     AltName: Full=Neuropeptide tyrosine;
DE              Short=NPY;
DE   Contains:
DE     RecName: Full=C-flanking peptide of NPY;
DE              Short=CPON;
DE   Flags: Precursor;
GN   Name=NPY;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Ile de France; TISSUE=Hypothalamus;
RX   PubMed=14636633; DOI=10.1016/s0016-6480(03)00266-1;
RA   Pillon D., Caraty A., Fabre-Nys C., Bruneau G.;
RT   "Early decrease of proopiomelanocortin but not neuropeptide Y mRNA
RT   expression in the mediobasal hypothalamus of the ewe, during the estradiol-
RT   induced preovulatory LH surge.";
RL   Gen. Comp. Endocrinol. 134:264-272(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 6-95.
RA   Simmons J.M., Daniel J.A., Matteri R.L., Keisler D.H.;
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 29-64, AND AMIDATION AT TYR-64.
RX   PubMed=2599092; DOI=10.1016/0014-5793(89)81669-2;
RA   Sillard R., Agerberth B., Mutt V., Joernvall H.;
RT   "Sheep neuropeptide Y. A third structural type of a highly conserved
RT   peptide.";
RL   FEBS Lett. 258:263-265(1989).
CC   -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC       of gonadotrophin-release hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic vesicle, secretory vesicle,
CC       neuronal dense core vesicle {ECO:0000250|UniProtKB:P07808}.
CC   -!- TISSUE SPECIFICITY: One of the most abundant peptides in the nervous
CC       system. Also found in some chromaffin cells of the adrenal medulla.
CC   -!- PTM: The neuropeptide Y form is cleaved at Pro-30 by the prolyl
CC       endopeptidase FAP (seprase) activity (in vitro).
CC       {ECO:0000250|UniProtKB:P01303}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; AJ417904; CAD10677.1; -; mRNA.
DR   EMBL; AF095782; AAC69886.1; -; mRNA.
DR   PIR; S07052; S07052.
DR   RefSeq; NP_001009452.1; NM_001009452.1.
DR   AlphaFoldDB; P14765; -.
DR   BMRB; P14765; -.
DR   STRING; 9940.ENSOARP00000011701; -.
DR   Ensembl; ENSOART00020001098; ENSOARP00020000896; ENSOARG00020000795.
DR   GeneID; 443508; -.
DR   KEGG; oas:443508; -.
DR   CTD; 4852; -.
DR   eggNOG; ENOG502S2BU; Eukaryota.
DR   OrthoDB; 1542445at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:HGNC-UCL.
DR   GO; GO:0098992; C:neuronal dense core vesicle; ISS:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0008343; P:adult feeding behavior; ISS:HGNC-UCL.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0032100; P:positive regulation of appetite; ISS:HGNC-UCL.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Cytoplasmic vesicle;
KW   Direct protein sequencing; Neuropeptide; Phosphoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000269|PubMed:2599092"
FT   PEPTIDE         29..64
FT                   /note="Neuropeptide Y"
FT                   /evidence="ECO:0000269|PubMed:2599092"
FT                   /id="PRO_0000025331"
FT   PEPTIDE         68..97
FT                   /note="C-flanking peptide of NPY"
FT                   /id="PRO_0000025332"
FT   SITE            30..31
FT                   /note="Cleavage; by FAP"
FT                   /evidence="ECO:0000250|UniProtKB:P01303"
FT   MOD_RES         64
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:2599092"
FT   MOD_RES         83
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P01303"
SQ   SEQUENCE   97 AA;  10750 MW;  6C2209A361CF8583 CRC64;
     MLGSKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGDDA PAEDLARYYS ALRHYINLIT
     RQRYGKRSSP ETLISDLLMR ESTGNIPRTR LEDPSMW