ID   NPY_TYPNA               Reviewed;          97 AA.
AC   Q9PW68;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Pro-neuropeptide Y;
DE   Contains:
DE     RecName: Full=Neuropeptide Y;
DE     AltName: Full=Neuropeptide tyrosine;
DE              Short=NPY;
DE   Contains:
DE     RecName: Full=C-flanking peptide of NPY;
DE              Short=CPON;
DE   Flags: Precursor;
GN   Name=npy;
OS   Typhlonectes natans (Rubber eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Gymnophiona; Typhlonectidae; Typhlonectes.
OX   NCBI_TaxID=8456 {ECO:0000312|EMBL:AAD48033.1};
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAD48033.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64,
RP   TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
RC   TISSUE=Brain;
RX   PubMed=11287086; DOI=10.1016/s0196-9781(01)00334-5;
RA   Ebersole T.J., Conlon J.M., Goetz F.W., Boyd S.K.;
RT   "Characterization and distribution of neuropeptide Y in the brain of a
RT   caecilian amphibian.";
RL   Peptides 22:325-334(2001).
CC   -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC       of gonadotrophin-release hormone. {ECO:0000250|UniProtKB:P33689}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed throughout the brain with highest levels
CC       of expression in medial pallium, basal forebrain, preoptic area,
CC       midbrain tegmentum and trigeminal nucleus.
CC       {ECO:0000269|PubMed:11287086}.
CC   -!- MASS SPECTROMETRY: [Neuropeptide Y]: Mass=4246; Mass_error=4;
CC       Method=MALDI; Evidence={ECO:0000269|PubMed:11287086};
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; AF167559; AAD48033.1; -; mRNA.
DR   AlphaFoldDB; Q9PW68; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000269|PubMed:11287086"
FT   PEPTIDE         29..64
FT                   /note="Neuropeptide Y"
FT                   /id="PRO_0000025351"
FT   PEPTIDE         68..97
FT                   /note="C-flanking peptide of NPY"
FT                   /id="PRO_0000025352"
FT   MOD_RES         64
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:11287086"
SQ   SEQUENCE   97 AA;  11275 MW;  9682E9D89DFFB1C7 CRC64;
     MQGSMRLWLS VLTFTLSLLI CLGTLADAYP SKPDNPGEDA PAEDMAKYYS ALRHYINLIT
     RQRYGKRSNP ETMVSDVWWR ESTENIPRSR FEDPSMW