ID   NPY_XENLA               Reviewed;          97 AA.
AC   P33689; Q68ET5;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Pro-neuropeptide Y;
DE   Contains:
DE     RecName: Full=Neuropeptide Y;
DE     AltName: Full=Neuropeptide tyrosine;
DE              Short=NPY;
DE   Contains:
DE     RecName: Full=C-flanking peptide of NPY;
DE              Short=CPON;
DE   Flags: Precursor;
GN   Name=npy;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8439344; DOI=10.1006/bbrc.1993.1141;
RA   van Riel M.C.H.M., Tuinhof R., Roubos E.W., Martens G.J.M.;
RT   "Cloning and sequence analysis of hypothalamic cDNA encoding Xenopus
RT   preproneuropeptide Y.";
RL   Biochem. Biophys. Res. Commun. 190:948-951(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9397931; DOI=10.1016/0303-7207(94)90213-5;
RA   Griffin D., Minth C.D., Taylor W.L.;
RT   "Isolation and characterization of the Xenopus laevis cDNA and genomic
RT   homologs of neuropeptide Y.";
RL   Mol. Cell. Endocrinol. 101:1-10(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC       of gonadotrophin-release hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic vesicle, secretory vesicle,
CC       neuronal dense core vesicle {ECO:0000250|UniProtKB:P07808}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; L11294; AAA49913.1; -; mRNA.
DR   EMBL; L07413; AAA49917.1; -; mRNA.
DR   EMBL; S55577; AAB25447.1; -; mRNA.
DR   EMBL; L11296; AAA49914.1; -; mRNA.
DR   EMBL; BC080115; AAH80115.1; -; mRNA.
DR   PIR; JC1460; JC1460.
DR   RefSeq; NP_001081300.1; NM_001087831.1.
DR   RefSeq; NP_001161232.1; NM_001167760.1.
DR   AlphaFoldDB; P33689; -.
DR   DNASU; 397763; -.
DR   GeneID; 397763; -.
DR   GeneID; 780752; -.
DR   KEGG; xla:397763; -.
DR   KEGG; xla:780752; -.
DR   CTD; 397763; -.
DR   CTD; 780752; -.
DR   Xenbase; XB-GENE-6254241; npy.L.
DR   Xenbase; XB-GENE-942364; npy.S.
DR   OMA; QGTMRLW; -.
DR   OrthoDB; 1542445at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 397763; Expressed in brain and 3 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0098992; C:neuronal dense core vesicle; ISS:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Cytoplasmic vesicle;
KW   Neuropeptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         29..64
FT                   /note="Neuropeptide Y"
FT                   /id="PRO_0000025353"
FT   PEPTIDE         68..97
FT                   /note="C-flanking peptide of NPY"
FT                   /id="PRO_0000025354"
FT   MOD_RES         64
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        38
FT                   /note="E -> D (in Ref. 2; AAA49914)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        69
FT                   /note="S -> C (in Ref. 2; AAA49914)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        82
FT                   /note="N -> S (in Ref. 2; AAA49914)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   97 AA;  11378 MW;  48BD85D3E6A463E6 CRC64;
     MQGNMRLWMS VLTLCLSMLI CLGTFAEAYP SKPDNPGEDA PAEDMAKYYS ALRHYINLIT
     RQRYGKRSSP ETMLSDVWWR ENTENIPRSR FEDPPMW