NP_ADE40
ID NP_ADE40 Reviewed; 185 AA.
AC Q89532;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Pre-histone-like nucleoprotein {ECO:0000255|HAMAP-Rule:MF_04056};
DE AltName: Full=Pre-core protein VII {ECO:0000255|HAMAP-Rule:MF_04056};
DE Short=pVII {ECO:0000255|HAMAP-Rule:MF_04056};
DE Contains:
DE RecName: Full=Histone-like nucleoprotein {ECO:0000255|HAMAP-Rule:MF_04056};
DE Short=NP {ECO:0000255|HAMAP-Rule:MF_04056};
DE AltName: Full=Core protein VII {ECO:0000255|HAMAP-Rule:MF_04056};
GN Name=L2 {ECO:0000255|HAMAP-Rule:MF_04056};
OS Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40).
OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus F.
OX NCBI_TaxID=28284;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dugan;
RX PubMed=8263936; DOI=10.1006/jmbi.1993.1687;
RA Davison A.J., Telford E.A., Watson M.S., McBride K., Mautner V.;
RT "The DNA sequence of adenovirus type 40.";
RL J. Mol. Biol. 234:1308-1316(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Dugan;
RA Pieniazek N.J., Slemenda S.B., Pieniazek D., Luftig R.B.;
RL Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the inhibition of host immune response within
CC the nucleus. Interacts with cellular nucleosomes and immobilizes the
CC host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1
CC release out of the cell and thus decreases inflammation. Also plays a
CC role in the wrapping and condensation of the viral DNA. May also
CC promote viral genome import into the nucleus. {ECO:0000255|HAMAP-
CC Rule:MF_04056}.
CC -!- SUBUNIT: Interacts with the core-capsid bridging protein; this
CC interaction bridges the virus core to the capsid. Interacts with host
CC NPM1; this interaction might play a role in placing the pre-histone-
CC like nucleoprotein on the viral DNA or regulating viral gene
CC expression. Interacts with host HMGB1; this interaction inhibits host
CC immune response. {ECO:0000255|HAMAP-Rule:MF_04056}.
CC -!- SUBCELLULAR LOCATION: [Histone-like nucleoprotein]: Virion
CC {ECO:0000255|HAMAP-Rule:MF_04056}. Note=Located inside the capsid in
CC association with the viral DNA (core). Present in about 1070 copies per
CC virion. {ECO:0000255|HAMAP-Rule:MF_04056}.
CC -!- SUBCELLULAR LOCATION: [Pre-histone-like nucleoprotein]: Host nucleus,
CC host nucleolus {ECO:0000255|HAMAP-Rule:MF_04056}.
CC -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC {ECO:0000255|HAMAP-Rule:MF_04056}.
CC -!- PTM: Cleaved near the N-terminus by the viral protease during virion
CC maturation to form the mature protein. {ECO:0000255|HAMAP-
CC Rule:MF_04056}.
CC -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC are produced by alternative splicing and alternative polyadenylation of
CC the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC present in the N-terminus of all these mRNAs and is recognized by the
CC viral shutoff protein to provide expression although conventional
CC translation via ribosome scanning from the cap has been shut off in the
CC host cell. {ECO:0000255|HAMAP-Rule:MF_04056}.
CC -!- SIMILARITY: Belongs to the adenoviridae histone-like nucleoprotein
CC family. {ECO:0000255|HAMAP-Rule:MF_04056, ECO:0000305}.
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DR EMBL; L19443; AAC13963.1; -; Genomic_DNA.
DR EMBL; M86665; AAA42526.1; -; Genomic_DNA.
DR RefSeq; NP_040858.1; NC_001454.1.
DR DNASU; 2715931; -.
DR GeneID; 2715931; -.
DR Proteomes; UP000151954; Genome.
DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04056; ADV_PVII; 1.
DR InterPro; IPR004912; Adeno_VII.
DR Pfam; PF03228; Adeno_VII; 1.
PE 3: Inferred from homology;
KW Acetylation; DNA-binding; Host nucleus; Host-virus interaction;
KW Late protein; Phosphoprotein; Reference proteome;
KW Viral penetration into host nucleus; Virion; Virus entry into host cell.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT CHAIN 2..185
FT /note="Pre-histone-like nucleoprotein"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT /id="PRO_0000421435"
FT PROPEP 2..23
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT /id="PRO_0000036581"
FT CHAIN 24..185
FT /note="Histone-like nucleoprotein"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT /id="PRO_0000036582"
FT MOTIF 175..185
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT SITE 23..24
FT /note="Cleavage; by viral protease"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT MOD_RES 2
FT /note="N-acetylserine; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT MOD_RES 55
FT /note="Phosphothreonine; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT MOD_RES 172
FT /note="Phosphoserine; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
SQ SEQUENCE 185 AA; 20518 MW; 4FBB0E53EF218A9E CRC64;
MSILISPDNN TGWGLCSAGM YGGAKRRSSQ HPVRVRGHYR APWGAYTRGV ISRRTTVDDV
IDSVVADAQR YTRPVATSTV DSVIDSVVAN ARRYAQRKRR LQRRRRRPTA AMTAARAVLR
RAQRIGRRAM RRAAASASAG RARRQAARQA AAAIASMAQP RRGNIYWVRD ASGVRVPVRS
RPPRS
