ID   NP_ADES1                Reviewed;         115 AA.
AC   Q8JN70;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Pre-histone-like nucleoprotein {ECO:0000255|HAMAP-Rule:MF_04056};
DE   AltName: Full=Pre-core protein VII {ECO:0000255|HAMAP-Rule:MF_04056};
DE            Short=pVII {ECO:0000255|HAMAP-Rule:MF_04056};
DE   Contains:
DE     RecName: Full=Histone-like nucleoprotein {ECO:0000255|HAMAP-Rule:MF_04056};
DE              Short=NP {ECO:0000255|HAMAP-Rule:MF_04056};
DE     AltName: Full=Core protein VII {ECO:0000255|HAMAP-Rule:MF_04056};
GN   Name=L2 {ECO:0000255|HAMAP-Rule:MF_04056};
OS   Snake adenovirus serotype 1 (SnAdV-1).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Atadenovirus.
OX   NCBI_TaxID=189830;
OH   NCBI_TaxID=94885; Pantherophis guttatus (Corn snake) (Elaphe guttata).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12237421; DOI=10.1099/0022-1317-83-10-2403;
RA   Farkas S.L., Benko M., Elo P.T., Ursu K., Dan A., Ahne W., Harrach B.;
RT   "Genetic analysis of an adenovirus isolated from corn snake (Elaphe
RT   guttata) implies common origin with the members of the proposed new genus
RT   Atadenovirus.";
RL   J. Gen. Virol. 83:2403-2410(2002).
CC   -!- FUNCTION: Plays a role in the inhibition of host immune response within
CC       the nucleus. Interacts with cellular nucleosomes and immobilizes the
CC       host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1
CC       release out of the cell and thus decreases inflammation. Also plays a
CC       role in the wrapping and condensation of the viral DNA. May also
CC       promote viral genome import into the nucleus. {ECO:0000255|HAMAP-
CC       Rule:MF_04056}.
CC   -!- SUBUNIT: Interacts with the core-capsid bridging protein; this
CC       interaction bridges the virus core to the capsid. Interacts with host
CC       NPM1; this interaction might play a role in placing the pre-histone-
CC       like nucleoprotein on the viral DNA or regulating viral gene
CC       expression. Interacts with host HMGB1; this interaction inhibits host
CC       immune response. {ECO:0000255|HAMAP-Rule:MF_04056}.
CC   -!- SUBCELLULAR LOCATION: [Histone-like nucleoprotein]: Virion
CC       {ECO:0000255|HAMAP-Rule:MF_04056}. Note=Located inside the capsid in
CC       association with the viral DNA (core). Present in about 1070 copies per
CC       virion. {ECO:0000255|HAMAP-Rule:MF_04056}.
CC   -!- SUBCELLULAR LOCATION: [Pre-histone-like nucleoprotein]: Host nucleus,
CC       host nucleolus {ECO:0000255|HAMAP-Rule:MF_04056}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000255|HAMAP-Rule:MF_04056}.
CC   -!- PTM: Cleaved near the N-terminus by the viral protease during virion
CC       maturation to form the mature protein. {ECO:0000255|HAMAP-
CC       Rule:MF_04056}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell. {ECO:0000255|HAMAP-Rule:MF_04056}.
CC   -!- SIMILARITY: Belongs to the adenoviridae histone-like nucleoprotein
CC       family. {ECO:0000255|HAMAP-Rule:MF_04056, ECO:0000305}.
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DR   EMBL; DQ106414; AAL92449.1; -; Genomic_DNA.
DR   RefSeq; YP_001552252.1; NC_009989.1.
DR   GeneID; 10973894; -.
DR   KEGG; vg:10973894; -.
DR   Proteomes; UP000136605; Genome.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04056; ADV_PVII; 1.
DR   InterPro; IPR004912; Adeno_VII.
DR   Pfam; PF03228; Adeno_VII; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Host nucleus; Host-virus interaction; Late protein;
KW   Phosphoprotein; Reference proteome; Viral penetration into host nucleus;
KW   Virion; Virus entry into host cell.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT   CHAIN           2..115
FT                   /note="Pre-histone-like nucleoprotein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT                   /id="PRO_0000439845"
FT   PROPEP          2..23
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT                   /id="PRO_0000439846"
FT   CHAIN           24..115
FT                   /note="Histone-like nucleoprotein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT                   /id="PRO_0000425940"
FT   REGION          85..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           ?114..115
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04056"
FT   COMPBIAS        87..101
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   115 AA;  13459 MW;  1AEE09BF53C8D166 CRC64;
     MPILISPSDN TGWGLGKLRI RATGLTFTDS TPVSVRHYFR DSGGQRNGRA TRAHLRRNLK
     KYRRKHDRRT HTRRVQPDVI LIKAGRRTAR SARRRSARKS RSEKTGPRIR YTRRI