ID   AROF_NEUCR              Reviewed;         481 AA.
AC   P80576; Q7SD77;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 2.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase;
DE            EC=2.5.1.54;
DE   AltName: Full=3-deoxy-D-arabino-heptulosonate 7-phosphate synthase;
DE   AltName: Full=DAHP synthase;
DE   AltName: Full=Phospho-2-keto-3-deoxyheptonate aldolase;
GN   Name=aro-8; Synonyms=aroh; ORFNames=NCU02785;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [2]
RP   PROTEIN SEQUENCE OF 43-72 AND 204-258.
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=8760910; DOI=10.1099/13500872-142-8-1973;
RA   Walker G.E., Dunbar B., Hunter I.S., Nimmo H.G., Coggins J.R.;
RT   "Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-
RT   phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus
RT   and Neurospora crassa.";
RL   Microbiology 142:1973-1982(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- SIMILARITY: Belongs to the class-II DAHP synthase family.
CC       {ECO:0000305}.
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DR   EMBL; CM002236; EAA34705.1; -; Genomic_DNA.
DR   RefSeq; XP_963941.1; XM_958848.2.
DR   AlphaFoldDB; P80576; -.
DR   SMR; P80576; -.
DR   STRING; 5141.EFNCRP00000002275; -.
DR   EnsemblFungi; EAA34705; EAA34705; NCU02785.
DR   GeneID; 3880090; -.
DR   KEGG; ncr:NCU02785; -.
DR   VEuPathDB; FungiDB:NCU02785; -.
DR   HOGENOM; CLU_026885_0_1_1; -.
DR   InParanoid; P80576; -.
DR   OMA; KVMMQMA; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 2.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002480; DAHP_synth_2.
DR   PANTHER; PTHR21337; PTHR21337; 1.
DR   Pfam; PF01474; DAHP_synth_2; 1.
PE   1: Evidence at protein level;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Direct protein sequencing; Reference proteome; Transferase.
FT   CHAIN           1..481
FT                   /note="Phospho-2-dehydro-3-deoxyheptonate aldolase"
FT                   /id="PRO_0000140853"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        251
FT                   /note="R -> T (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        255
FT                   /note="H -> A (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        258
FT                   /note="V -> Q (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   481 AA;  54067 MW;  F909473F599FD9BF CRC64;
     MSQQTTPNAP GWAPDSWRSK PIKQCPEYPD KAALEKATNE LKTLPPIVLP NEIIRLREHL
     RDVAQGKAFL LQGGDCAELF SYCQQDVIES KIKLLLQMSL VLLWGADKPV VRIGRMAGQY
     AKPRSSPVET INGKEVPSFR GDILNGFHPD ERELDPNRLV RAYQYSSATL NYIRGAIGSG
     IADLHGPLDW GLGHVRDPAL KSKYQETVDR IQEMLRFMHT IGADQNEKLS TVELFTSHEG
     LLLEYEEPLT RLLNHPSVRS YPPDSTTPPK KEYYNTSAHF LWIGDRTRQI DHAHVEYFRG
     IANPIGVKIG PSTPTSDLLP MLRTLNPNRE PGKVTLITRY GADKVASLLP AHIRTVESSE
     YARTVVWQCD PMHGNTQSVS GGIKTRKFSD IFSELQQTLR IHKEEKSYLG GMHLELTGDA
     VTECLGGGAG LDEDDLSTNY TSFCDPRLNE KQALELAFLV ADHYRQERKE KEAERRKSSV
     V