ID   NQRA_ACTP2              Reviewed;         449 AA.
AC   A3MYM2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=APL_0150;
OS   Actinobacillus pleuropneumoniae serotype 5b (strain L20).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=416269;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L20;
RX   PubMed=18065534; DOI=10.1128/jb.01845-07;
RA   Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M.,
RA   Nash J.H.E.;
RT   "The complete genome sequence of Actinobacillus pleuropneumoniae L20
RT   (serotype 5b).";
RL   J. Bacteriol. 190:1495-1496(2008).
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
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DR   EMBL; CP000569; ABN73258.1; -; Genomic_DNA.
DR   RefSeq; WP_005595863.1; NC_009053.1.
DR   AlphaFoldDB; A3MYM2; -.
DR   SMR; A3MYM2; -.
DR   STRING; 416269.APL_0150; -.
DR   EnsemblBacteria; ABN73258; ABN73258; APL_0150.
DR   GeneID; 66258992; -.
DR   KEGG; apl:APL_0150; -.
DR   eggNOG; COG1726; Bacteria.
DR   HOGENOM; CLU_046656_0_0_6; -.
DR   OMA; IKQRPYD; -.
DR   Proteomes; UP000001432; Chromosome.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Reference proteome; Sodium; Sodium transport;
KW   Translocase; Transport; Ubiquinone.
FT   CHAIN           1..449
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_1000060109"
SQ   SEQUENCE   449 AA;  48604 MW;  62CBDD17A8435418 CRC64;
     MITIKKGLDL PIAGTPAQVI HNGNTVNEVA MLGEEYVGMR PSMKVREGDV VKKGQVLFED
     KKNPGVVFTA PASGTVVTIN RGEKRVLQSV VIKVEGDEQI TFTRYEAAQL ASLSAEQVKQ
     NLIESGLWTA FRTRPFSKVP ALDAIPSSIF VNAMDTNPLA ADPEVVLKEY ETDFKDGLTV
     LTRLFNGQKP VYLCKDADSN IPLSPAIEGI TIKSFSGVHP AGLVGTHIHF VDPVGATKQV
     WHLNYQDVIA IGKLFTTGEL FTDRIISLAG PQVKNPRLVR TRLGANLSQL TANELNAGEN
     RVISGSVLSG ATAAGPVDYL GRYALQVSVL AEGREKELFG WIMPGSDKFS ITRTVLGHFG
     KKLFNFTTAV HGGERAMVPI GAYERVMPLD IIPTLLLRDL AAGDTDSAQN LGCLELDEED
     LALCTYVCPG KNNYGPMLRA ALEKIEKEG