ID   NQRA_ACTSZ              Reviewed;         443 AA.
AC   A6VLX6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=Asuc_0599;
OS   Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 /
OS   130Z).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=339671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z;
RX   PubMed=21118570; DOI=10.1186/1471-2164-11-680;
RA   McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A.,
RA   Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L.,
RA   Burkhart K.B., Harkins V., Vieille C.;
RT   "A genomic perspective on the potential of Actinobacillus succinogenes for
RT   industrial succinate production.";
RL   BMC Genomics 11:680-680(2010).
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
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DR   EMBL; CP000746; ABR73973.1; -; Genomic_DNA.
DR   RefSeq; WP_012072353.1; NC_009655.1.
DR   AlphaFoldDB; A6VLX6; -.
DR   SMR; A6VLX6; -.
DR   STRING; 339671.Asuc_0599; -.
DR   PRIDE; A6VLX6; -.
DR   EnsemblBacteria; ABR73973; ABR73973; Asuc_0599.
DR   KEGG; asu:Asuc_0599; -.
DR   eggNOG; COG1726; Bacteria.
DR   HOGENOM; CLU_046656_0_0_6; -.
DR   OMA; IKQRPYD; -.
DR   OrthoDB; 688908at2; -.
DR   Proteomes; UP000001114; Chromosome.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Reference proteome; Sodium; Sodium transport;
KW   Translocase; Transport; Ubiquinone.
FT   CHAIN           1..443
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_1000072307"
SQ   SEQUENCE   443 AA;  48022 MW;  D670E5C384F52D05 CRC64;
     MITIKKGLDL PIAGKPEQVI RDGNAVTEVA MLGEEYVGMR PSMKVREGDT VKKGQVLFED
     KKNPGVVFTA PASGTVTAIN RGAKRVLQSV VIRVGGNEQV TFEKYDVAAL NQLTGEQVRR
     NLQASGLWTA LRTRPFSKVP AIDAVPSSIF VNAMDSNPLA ADPAVIINEY AEDFTNGLTV
     LTRLHDKVNL VKSAGSNITA VGAVKVHEFG GKHPAGLVGT HIHFIDPVSL TKTVWHLNYQ
     DVIAIGKLFT TGELFVERVV SLAGPQVKNP RLVRTVSGAN LTQLTENELN AGENRVISGS
     VLYGAKAEGP HNYLGRYALQ VSVLAEDTEK EFFGWISPQA NKFSITRTVL GHFGKKLFNF
     TTAENGGHRA MVPIGSYERV MPLDILPTLL LRDLEVGDTD SAQSLGCLEL DEEDLALCTF
     VDPGKADYGS FLRQALDKIE KEG