ID   NQRA_CHLCV              Reviewed;         470 AA.
AC   Q824Y6;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=CCA_00002;
OS   Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)
OS   (Chlamydophila caviae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=227941;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-813 / DSM 19441 / 03DC25 / GPIC;
RX   PubMed=12682364; DOI=10.1093/nar/gkg321;
RA   Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T.,
RA   Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A.,
RA   Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O.,
RA   Salzberg S.L., Hsia R.-C., McClarty G., Rank R.G., Bavoil P.M.,
RA   Fraser C.M.;
RT   "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC):
RT   examining the role of niche-specific genes in the evolution of the
RT   Chlamydiaceae.";
RL   Nucleic Acids Res. 31:2134-2147(2003).
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
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DR   EMBL; AE015925; AAP04755.1; -; Genomic_DNA.
DR   RefSeq; WP_011005976.1; NC_003361.3.
DR   AlphaFoldDB; Q824Y6; -.
DR   SMR; Q824Y6; -.
DR   STRING; 227941.CCA_00002; -.
DR   PRIDE; Q824Y6; -.
DR   EnsemblBacteria; AAP04755; AAP04755; CCA_00002.
DR   KEGG; cca:CCA_00002; -.
DR   eggNOG; COG1726; Bacteria.
DR   HOGENOM; CLU_046656_0_0_0; -.
DR   OMA; IKQRPYD; -.
DR   OrthoDB; 688908at2; -.
DR   Proteomes; UP000002193; Chromosome.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Sodium; Sodium transport; Translocase; Transport;
KW   Ubiquinone.
FT   CHAIN           1..470
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_0000214193"
SQ   SEQUENCE   470 AA;  52420 MW;  0994845CA9871523 CRC64;
     MKIAITRGLD LSLQGSPKES GFLKRIDPAL VSVDLRPYSA LALKLKVEQD DVISSGSPIA
     EYKNFPGVFI TSPVSGIVKE IRRGEKRSLL DVVIKKTPGQ NLTEYSYDLS KLSRAELLEI
     FKKEGLFALF KQRPFDIPAL PTQTPRDVFI NLADNRPFTP STEKQLAVFS SREEGFYVFN
     VGVRAVAKLF GLCPHIVSTD RLALPEKDLK SIAHLHKITG PYPSGSPSTH IHYIAPITNE
     KDIVFTLSFQ EVLTIGHLFL KGRILNEQVV ALAGSGLKSS LRRYVITTKG ANFESLLPLQ
     DISSDVSLIS GDPLTGRLCD RESLPCLGMR DSTISVLPNP KTRQAFNFLR LGINKPTHTR
     TYLSGFLKRK HTYMDPDTNL HGETRPIIDT EIYDKVMPLK IPVVPLIKAV ITKDFELACM
     LGFLEVCPED FALPTFIDPS KTEMLTIIKD ALKDYAKETG ILNLEYEDKE