NQRA_CHLPN
ID NQRA_CHLPN Reviewed; 467 AA.
AC Q9Z7G2;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; Synonyms=nqr1;
GN OrderedLocusNames=CPn_0743, CP_0002, CpB0771;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC ubiquinol by two successive reactions, coupled with the transport of
CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC probably involved in the second step, the conversion of ubisemiquinone
CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00425};
CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00425}.
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DR EMBL; AE001363; AAD18882.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF37899.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98950.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98700.1; -; Genomic_DNA.
DR PIR; D86583; D86583.
DR PIR; E72040; E72040.
DR RefSeq; NP_224939.1; NC_000922.1.
DR RefSeq; WP_010883381.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z7G2; -.
DR SMR; Q9Z7G2; -.
DR STRING; 115711.CP_0002; -.
DR EnsemblBacteria; AAD18882; AAD18882; CPn_0743.
DR EnsemblBacteria; AAF37899; AAF37899; CP_0002.
DR GeneID; 45050798; -.
DR KEGG; cpa:CP_0002; -.
DR KEGG; cpj:nqrA; -.
DR KEGG; cpn:CPn_0743; -.
DR KEGG; cpt:CpB0771; -.
DR PATRIC; fig|115713.3.peg.819; -.
DR eggNOG; COG1726; Bacteria.
DR HOGENOM; CLU_046656_0_0_0; -.
DR OMA; IKQRPYD; -.
DR OrthoDB; 688908at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00425; NqrA; 1.
DR InterPro; IPR008703; NqrA.
DR InterPro; IPR022615; NqrA_C_domain.
DR PANTHER; PTHR37839; PTHR37839; 1.
DR Pfam; PF05896; NQRA; 1.
DR Pfam; PF11973; NQRA_SLBB; 1.
DR TIGRFAMs; TIGR01936; nqrA; 1.
PE 3: Inferred from homology;
KW Ion transport; NAD; Sodium; Sodium transport; Translocase; Transport;
KW Ubiquinone.
FT CHAIN 1..467
FT /note="Na(+)-translocating NADH-quinone reductase subunit
FT A"
FT /id="PRO_0000214195"
SQ SEQUENCE 467 AA; 52266 MW; 84CE73278BA0BFD6 CRC64;
MKITVNRGLD LSLQGSPKES GFYNKIDPEF VSIDLRPFQP LSLKLKVEQG DAVCSGAPIA
EYKHFPNTYI TSHVSGVVTA IRRGNKRSLL DVIIKKTPGP TSTEYTYDLQ TLSRSDLSEI
FKENGLFALI KQRPFDIPAI PTQTPRDVFI NLADNRPFTP SPEKHLALFS SREEGFYVFV
VGVRAIAKLF GLRPHIVFRD RLTLPTQELK TIAHLHTVSG PFPSGSPSIH IHSVAPITNE
KEVVFTLSFQ DVLTIGHLFL KGRILHEQVT ALAGTALKSS LRRYVITTKG ASFSSLINLN
DISDNDTLIS GDPLTGRLCK KEEEPFLGFR DHSISVLHNP TKRELFSFLR IGFNKPTFTK
TYLSGFFKKK RTYTNPDTNL HGETRPIIDT DIYDKVMPMR IPVVPLIKAV ITKNFDLANE
LGFLEVCGED FALPTLIDPS KTEMLTIVKE SLIEYAKESG ILTPHQD
