ID   NQRA_CHLT2              Reviewed;         465 AA.
AC   B0B8K9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=CTL0002;
OS   Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=471472;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=18032721; DOI=10.1101/gr.7020108;
RA   Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA   Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA   Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT   "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT   venereum isolates.";
RL   Genome Res. 18:161-171(2008).
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
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DR   EMBL; AM884176; CAP03446.1; -; Genomic_DNA.
DR   RefSeq; WP_009873252.1; NC_010287.1.
DR   RefSeq; YP_001654093.1; NC_010287.1.
DR   AlphaFoldDB; B0B8K9; -.
DR   SMR; B0B8K9; -.
DR   EnsemblBacteria; CAP03446; CAP03446; CTL0002.
DR   KEGG; ctb:CTL0002; -.
DR   PATRIC; fig|471472.4.peg.2; -.
DR   HOGENOM; CLU_046656_0_0_0; -.
DR   OMA; IKQRPYD; -.
DR   Proteomes; UP000000795; Chromosome.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Sodium; Sodium transport; Translocase; Transport;
KW   Ubiquinone.
FT   CHAIN           1..465
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_1000124170"
SQ   SEQUENCE   465 AA;  51757 MW;  8D68DEEA250C8FAE CRC64;
     MKIVVSRGLD LSLKGAPKES GFCGKVDPTY VSVDLRPFAP LPLEVKVTPG DQVTAGSPLA
     EYKLFSGVFI TSPVDGEVVE IRRGNKRALL EIVIKKKPGI SQTKFSYDLQ SLTQKDLLEV
     FKKEGLFALF KQRPFDIPAL PTQSPRDVFI NLADNRPFTP SVEKHLSLFS SKEDGYYIFV
     VGVQAIAKLF GLKPHIISTD RLTLPTQDLV SIAHLHTIDG PFPSGSPSTH IHHIARIRNE
     RDVVFTISFQ EVLSIGHLFL KGFVLGQQIV ALAGSALPPS QRKYLITAKG ASFSDLLPKD
     IFSSDEITLI SGDPLTGRLC KKEENPCLGM RDHTITLLPN PKTRESFSFL RLGWNKLTVT
     RTYLSGFFKR KRVFMDMDTN MHGEKRPIID AEIYERVSAI PVPVALIIKA LETQNFEEAC
     RLGLLEVAPE DFALPTFIDP SKTEMFSIVK ESLLRYAKEN VVTSS