ID   NQRA_GLAP5              Reviewed;         448 AA.
AC   B8F5U5;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=HAPS_1079;
OS   Glaesserella parasuis serovar 5 (strain SH0165) (Haemophilus parasuis).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Glaesserella.
OX   NCBI_TaxID=557723;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SH0165;
RX   PubMed=19074396; DOI=10.1128/jb.01682-08;
RA   Yue M., Yang F., Yang J., Bei W., Cai X., Chen L., Dong J., Zhou R.,
RA   Jin M., Jin Q., Chen H.;
RT   "Complete genome sequence of Haemophilus parasuis SH0165.";
RL   J. Bacteriol. 191:1359-1360(2009).
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
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DR   EMBL; CP001321; ACL32697.1; -; Genomic_DNA.
DR   RefSeq; WP_015939612.1; NC_011852.1.
DR   AlphaFoldDB; B8F5U5; -.
DR   SMR; B8F5U5; -.
DR   STRING; 557723.HAPS_1079; -.
DR   EnsemblBacteria; ACL32697; ACL32697; HAPS_1079.
DR   GeneID; 66618040; -.
DR   KEGG; hap:HAPS_1079; -.
DR   PATRIC; fig|557723.8.peg.1075; -.
DR   HOGENOM; CLU_046656_0_0_6; -.
DR   OMA; IKQRPYD; -.
DR   Proteomes; UP000006743; Chromosome.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Reference proteome; Sodium; Sodium transport;
KW   Translocase; Transport; Ubiquinone.
FT   CHAIN           1..448
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_1000134930"
SQ   SEQUENCE   448 AA;  48493 MW;  2C7A69C544CC0908 CRC64;
     MITIKQGLDL PIAGKPEQVI HNGNTVNEVA VLGEEYVGMR PSMKVREGDV VKKGQVLFED
     KKNAGVVFTA PASGTIVAIN RGEKRVLQSV VIKVEGDEQV TFERYNASEL SSLTADQVKQ
     NLVNSGLWTA FRTRPFSKVP ALDAVPSSIF VNAMDTNPLA TDPEVVLNEH KQDFVDGLTV
     LSRLFDGQKI IHLCRAPDSN IPTAEVANVK VTSFAGPHPA GLSGTHIHFI DPVSVTKSVW
     YLNYQDVIAI GKLFTTGELY TDRVVSLAGP QVKKPRLVRT QLGANLSQLT AGELAEGENR
     VISGSVLSGA KAVGVHDYLG RYALQVSVIA EGREQEFLGM IAPYSHKFSI TRTVLGAFSK
     KLFNFTTAVN GSERAMVPIG SYERVMPLDI LPTLLLRDLA SGDTDSAQAL GCLELDEEDL
     ALCTFVCPGK NNYAPMLRAA LDKIEKEG