ID   NQRA_HAEDU              Reviewed;         443 AA.
AC   Q7VNU9;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=HD_0379;
OS   Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=233412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RA   Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA   Nguyen D., Wang J., Forst C., Hood L.;
RT   "The complete genome sequence of Haemophilus ducreyi.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
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DR   EMBL; AE017143; AAP95349.1; -; Genomic_DNA.
DR   RefSeq; WP_010944402.1; NC_002940.2.
DR   AlphaFoldDB; Q7VNU9; -.
DR   SMR; Q7VNU9; -.
DR   STRING; 233412.HD_0379; -.
DR   DNASU; 1490378; -.
DR   EnsemblBacteria; AAP95349; AAP95349; HD_0379.
DR   KEGG; hdu:HD_0379; -.
DR   eggNOG; COG1726; Bacteria.
DR   HOGENOM; CLU_046656_0_0_6; -.
DR   OMA; IKQRPYD; -.
DR   Proteomes; UP000001022; Chromosome.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Reference proteome; Sodium; Sodium transport;
KW   Translocase; Transport; Ubiquinone.
FT   CHAIN           1..443
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_0000214197"
SQ   SEQUENCE   443 AA;  47878 MW;  BBFE7ABF584A0272 CRC64;
     MITIKKGLDL PIAASPAQVI HNGNTVNEVA MLGEEYVGMR PSMKVREGDL VKKGQVLFED
     KKNAGVVFTA PASGTVVAIN RGEKRVLQSV VIKVEGDEQI TFTRYEAAQL ASLSAEQVRA
     NLIDAGLWIA FRTRPFSKVP AVDATPASIF VNAMDTNPLS ADPAVIINEY KNDFEYGLTV
     LIRLGVKVNL VKAAGVNIPT VDGITVHEFA GKHPAGLVGT HIHFIDPVNL TKTVWHLNYQ
     DVIAFGKLFT TGELFTDRVV ALAGPQVKTP RLVRTRLGAN LSQLTTGELN VGENRIISGS
     VLSGATASGP VDFLGRYALQ VSVLLEGCEK ELLGWVMPGS DKYSITRTVL GHFRKKLFNF
     TTAVHGGERA MVPIGAYERV MPLDIIPTLL LRDLAAGDTD SAQNLGCLEL DEEDLALCTY
     VCPGKNNYGP MLRTALDKIE KEG