NQRA_HAEIN
ID NQRA_HAEIN Reviewed; 447 AA.
AC P43955; P43956;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=HI_0164;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP SEQUENCE REVISION.
RA White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D.;
RL Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-75.
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RA Barcak G.J., Heimer S.R.;
RL Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION AS NQR SYSTEM.
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=8601449; DOI=10.1016/0014-5793(96)00114-7;
RA Hayashi M., Nakayama Y., Unemoto T.;
RT "Existence of Na+-translocating NADH-quinone reductase in Haemophilus
RT influenzae.";
RL FEBS Lett. 381:174-176(1996).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=10675023;
RX DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA Fountoulakis M.;
RT "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL Electrophoresis 21:411-429(2000).
CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC ubiquinol by two successive reactions, coupled with the transport of
CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC probably involved in the second step, the conversion of ubisemiquinone
CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00425};
CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00425}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA62134.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; L42023; AAC21836.1; -; Genomic_DNA.
DR EMBL; U20229; AAA62134.1; ALT_FRAME; Genomic_DNA.
DR PIR; I64002; I64002.
DR RefSeq; NP_438334.1; NC_000907.1.
DR RefSeq; WP_005694115.1; NC_000907.1.
DR AlphaFoldDB; P43955; -.
DR SMR; P43955; -.
DR STRING; 71421.HI_0164; -.
DR DNASU; 951076; -.
DR EnsemblBacteria; AAC21836; AAC21836; HI_0164.
DR KEGG; hin:HI_0164; -.
DR PATRIC; fig|71421.8.peg.170; -.
DR eggNOG; COG1726; Bacteria.
DR HOGENOM; CLU_046656_0_0_6; -.
DR OMA; IKQRPYD; -.
DR PhylomeDB; P43955; -.
DR BioCyc; HINF71421:G1GJ1-176-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00425; NqrA; 1.
DR InterPro; IPR008703; NqrA.
DR InterPro; IPR022615; NqrA_C_domain.
DR PANTHER; PTHR37839; PTHR37839; 1.
DR Pfam; PF05896; NQRA; 1.
DR Pfam; PF11973; NQRA_SLBB; 1.
DR TIGRFAMs; TIGR01936; nqrA; 1.
PE 1: Evidence at protein level;
KW Ion transport; NAD; Reference proteome; Sodium; Sodium transport;
KW Translocase; Transport; Ubiquinone.
FT CHAIN 1..447
FT /note="Na(+)-translocating NADH-quinone reductase subunit
FT A"
FT /id="PRO_0000214198"
SQ SEQUENCE 447 AA; 48884 MW; 4670C93FB5FF0912 CRC64;
MITIKKGLDL PIAGKPAQVI HSGNAVNQVA ILGEEYVGMR PSMKVREGDV VKKGQVLFED
KKNPGVIFTA PASGTITAIN RGEKRVLQSV VINVEGDEKI TFAKYSTEQL NTLSSEQVKQ
NLIESGLWTA LRTRPFSKVP SIESEASSIF VNAMDTNPLA ADPSVVLKEY SQDFTNGLTV
LSRLFPSKPL HLCKAGDSNI PTADLENLQI HDFTGVHPAG LVGTHIHFID PVGIQKTVWH
INYQDVIAVG KLFTTGELYS ERVISLAGPQ VKEPRLVRTT IGANLSQLTQ NELSAGKNRV
ISGSVLCGQI AKDSHDYLGR YALQVSVIAE GNEKEFFGWI MPQANKYSVT RTVLGHFSKK
LFNFTTSENG GERAMVPIGS YERVMPLDIL PTLLLRDLIV GDTDGAQELG CLELDEEDLA
LCSFVCPGKY EYGSILRQVL DKIEKEG
