ID   NQRA_HAES1              Reviewed;         446 AA.
AC   Q0I5X6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=HS_1693;
OS   Haemophilus somnus (strain 129Pt) (Histophilus somni).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=205914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=129Pt;
RX   PubMed=17172329; DOI=10.1128/jb.01422-06;
RA   Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O.,
RA   Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N.,
RA   Xie G., Inzana T.J.;
RT   "Complete genome sequence of Haemophilus somnus (Histophilus somni) strain
RT   129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus
RT   influenzae Rd.";
RL   J. Bacteriol. 189:1890-1898(2007).
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
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DR   EMBL; CP000436; ABI25961.1; -; Genomic_DNA.
DR   RefSeq; WP_011609837.1; NC_008309.1.
DR   AlphaFoldDB; Q0I5X6; -.
DR   SMR; Q0I5X6; -.
DR   STRING; 205914.HS_1693; -.
DR   EnsemblBacteria; ABI25961; ABI25961; HS_1693.
DR   KEGG; hso:HS_1693; -.
DR   eggNOG; COG1726; Bacteria.
DR   HOGENOM; CLU_046656_0_0_6; -.
DR   OMA; IKQRPYD; -.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Sodium; Sodium transport; Translocase; Transport;
KW   Ubiquinone.
FT   CHAIN           1..446
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_1000060116"
SQ   SEQUENCE   446 AA;  48549 MW;  1B5A4DFF11ADC23B CRC64;
     MITIKKGLDL PIAGKPEQVI HNGNAVKEVA LLGEEYVGMR PSMKVREGDV VKKGQVLFED
     KKNPGIVFTA PASGTVTAIN RGAKRVLQSV VIKVEGNEQI TFTQYNEDEL KKLTSDQVRQ
     NLQSSGLWTA LRTRPFSKVP ASDAVPSSIF VNAMDTNPLS ANPEIVLKEH WQDFTDGLTV
     LSRLHEGKLH LCKAGDSNIP TIDLPNLAVH DFSGPHPAGL SGTHIHFIDP VSVTKSVWYL
     NYQDVIAIGK LFTTGEIYTD RVVSLAGPQV KNPRLIRTQL GANLSHLTEN ELSAGENRVI
     SGSVLSGNTA IGPYNYLGRY ALQVSVIAEG REKEFLGWIM PGKNKFSITR TVLGHFSSKL
     FNFTSAVNGG HRAMVPIGAY ERVVPLDIIP TLLLRDLASG DTDSAQALGC LELDEEDLAL
     CTFVCPGKNE YGPMLRAALD KIEKEG