ID   NQRA_KLEP7              Reviewed;         447 AA.
AC   A6T521;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425};
GN   OrderedLocusNames=KPN78578_02310; ORFNames=KPN_00239;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
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DR   EMBL; CP000647; ABR75692.1; -; Genomic_DNA.
DR   RefSeq; WP_002889702.1; NC_009648.1.
DR   AlphaFoldDB; A6T521; -.
DR   SMR; A6T521; -.
DR   STRING; 272620.KPN_00239; -.
DR   jPOST; A6T521; -.
DR   EnsemblBacteria; ABR75692; ABR75692; KPN_00239.
DR   KEGG; kpn:KPN_00239; -.
DR   HOGENOM; CLU_046656_0_0_6; -.
DR   OMA; IKQRPYD; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Reference proteome; Sodium; Sodium transport;
KW   Translocase; Transport; Ubiquinone.
FT   CHAIN           1..447
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_1000060118"
SQ   SEQUENCE   447 AA;  48417 MW;  DDC78669DA5FED8B CRC64;
     MIKITKGLDL PIAGMPLQQI SPAPAVKRVA LLGEEYVGMR PAMAVKEGDR VKKGQILFED
     KKIPGVCFTA PASGIVSAIH RGERRVLQSV VIDIEGNDAV AFTRYAADAL AELPRDTVQQ
     QLLASGQWTA LRTRPFSKTP LPGSTPAAIF VNAMDTNPLA AEPQPIILAE RAAFDAGLTV
     LTRLTDGKVH VCQPSGGKLG GHPLGQVCFN QFSGPHPAGL PGTHIHFLEP VSLNKQVWHL
     NYQDAIAIGK LFLDGELYCE RIIALGGPQV TSPRLVKTTL GASLEDLLAG ELQEGENRVI
     SGSVLSGARA HGPHAFLGRF HLQVSVVKEG REKELFGWVM PGKEKFSITR TTLGHFFKRK
     RFHFSTDTNG GERAMVPIGN YERVMPLDIL PTILLRDLLA GDTDSAQALG CLELDEEDLA
     LCTYVCPGKY EYGPALRSVL TRIEQEG