NQRA_MANSM
ID NQRA_MANSM Reviewed; 443 AA.
AC Q65VU4;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=MS0309;
OS Mannheimia succiniciproducens (strain MBEL55E).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Basfia.
OX NCBI_TaxID=221988;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MBEL55E;
RX PubMed=15378067; DOI=10.1038/nbt1010;
RA Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H.,
RA Jeong H., Hur C.G., Kim J.J.;
RT "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT succiniciproducens.";
RL Nat. Biotechnol. 22:1275-1281(2004).
CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC ubiquinol by two successive reactions, coupled with the transport of
CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC probably involved in the second step, the conversion of ubisemiquinone
CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00425};
CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00425}.
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DR EMBL; AE016827; AAU36916.1; -; Genomic_DNA.
DR RefSeq; WP_011199491.1; NC_006300.1.
DR AlphaFoldDB; Q65VU4; -.
DR SMR; Q65VU4; -.
DR STRING; 221988.MS0309; -.
DR EnsemblBacteria; AAU36916; AAU36916; MS0309.
DR KEGG; msu:MS0309; -.
DR eggNOG; COG1726; Bacteria.
DR HOGENOM; CLU_046656_0_0_6; -.
DR OMA; IKQRPYD; -.
DR OrthoDB; 688908at2; -.
DR Proteomes; UP000000607; Chromosome.
DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00425; NqrA; 1.
DR InterPro; IPR008703; NqrA.
DR InterPro; IPR022615; NqrA_C_domain.
DR PANTHER; PTHR37839; PTHR37839; 1.
DR Pfam; PF05896; NQRA; 1.
DR Pfam; PF11973; NQRA_SLBB; 1.
DR TIGRFAMs; TIGR01936; nqrA; 1.
PE 3: Inferred from homology;
KW Ion transport; NAD; Sodium; Sodium transport; Translocase; Transport;
KW Ubiquinone.
FT CHAIN 1..443
FT /note="Na(+)-translocating NADH-quinone reductase subunit
FT A"
FT /id="PRO_1000060119"
SQ SEQUENCE 443 AA; 48004 MW; 4236802D6AACC1A5 CRC64;
MITIKKGLDL PINGKPEQVI RDGNAVTEVA LLGEEYVGMR PSMKIHEGDT VKKGQILFED
KKNPGVVFTA PVSGTVTAIN RGAKRVLQSV VIRVEGNDQE TFAKYSPAEL VSLSSEQVRQ
NLQTSGLWTA LRTRPLSKIP AVDAVPSSIF VNAMDTNPLC ADPAVIINEY QADFTNGLTV
LTRLHNKVNL CKAAGSNIAS VDNVDSHEFA GVHPAGLVGT HIHFIDPVGI NKSVWHINYQ
DVIAIGKLFT TGELFTDRVV ALAGPQVKNP RLVRTNIGAN LSQLTANELA DGNNRVISGS
VLYGAKAEGA HDYLGRYALQ VSVIAEDTEK EFFGWISPQA NKYSITRTVL GHFGRKLFNF
TTAENGGHRA MVPIGSYERV MPLDILPTLL LRDLEVGDTD SAQALGALEL DEEDLALCTF
VCPGKADYGS FLRQALDKIE KEG
