ID   NQRA_NEIG2              Reviewed;         447 AA.
AC   B4RNF8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=NGK_1668;
OS   Neisseria gonorrhoeae (strain NCCP11945).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=521006;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCCP11945;
RX   PubMed=18586945; DOI=10.1128/jb.00566-08;
RA   Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.;
RT   "Complete genome sequence of Neisseria gonorrhoeae NCCP11945.";
RL   J. Bacteriol. 190:6035-6036(2008).
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
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DR   EMBL; CP001050; ACF30316.1; -; Genomic_DNA.
DR   RefSeq; WP_012503818.1; NC_011035.1.
DR   AlphaFoldDB; B4RNF8; -.
DR   SMR; B4RNF8; -.
DR   EnsemblBacteria; ACF30316; ACF30316; NGK_1668.
DR   GeneID; 66753626; -.
DR   KEGG; ngk:NGK_1668; -.
DR   HOGENOM; CLU_046656_0_0_4; -.
DR   OMA; IKQRPYD; -.
DR   OrthoDB; 688908at2; -.
DR   Proteomes; UP000002564; Chromosome.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Sodium; Sodium transport; Translocase; Transport;
KW   Ubiquinone.
FT   CHAIN           1..447
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_1000124173"
SQ   SEQUENCE   447 AA;  48713 MW;  5CB023C478794CC5 CRC64;
     MIKIKKGLNL PIAGRPEQVI YDGPAITEVA LLGEEYVGMR PSMKIKEGEA VKKGQVLFED
     KKNPGVVFTA PASGKIAAIH RGEKRVLQSV VIAVEGNDEI EFERYVPEAL AKLSSEEVRR
     NLIQSGLWTA LRTRPFSKIP AVDAEPFAIF VNAMDTNPLA ADPTVIIKEA AEDFKRGLLV
     LSRLTERKIH VCKAAGADVP SENAANIETH EFGGPHPAGL SGTHIHFIEP VGANKTVWTI
     NYQDVIAIGR LFVTGRLNTE RVVALGGLQV NKPRLLRTVL GAKVSQLTAG ELVDADNRVI
     SGSVLNGAIA QGAHDYLGRY HNQISVIEEG RGKELFGWVA PQPDKYSITR TTLGHFLKNK
     LFKFTTAVNG GDRAMVPIGT YERVMPLDIL PTLLLRDLIV GDTDSAQALG CLELDEEDLA
     LCSFVCPGKY EYGPLLRKVL ETIEKEG