NQRA_PASMU
ID NQRA_PASMU Reviewed; 446 AA.
AC Q9CLB1;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=PM1328;
OS Pasteurella multocida (strain Pm70).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Pasteurella.
OX NCBI_TaxID=272843;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pm70;
RX PubMed=11248100; DOI=10.1073/pnas.051634598;
RA May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT "Complete genomic sequence of Pasteurella multocida Pm70.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC ubiquinol by two successive reactions, coupled with the transport of
CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC probably involved in the second step, the conversion of ubisemiquinone
CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00425};
CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00425}.
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DR EMBL; AE004439; AAK03412.1; -; Genomic_DNA.
DR RefSeq; WP_010907129.1; NC_002663.1.
DR AlphaFoldDB; Q9CLB1; -.
DR SMR; Q9CLB1; -.
DR STRING; 747.DR93_578; -.
DR EnsemblBacteria; AAK03412; AAK03412; PM1328.
DR KEGG; pmu:PM1328; -.
DR PATRIC; fig|272843.6.peg.1339; -.
DR HOGENOM; CLU_046656_0_0_6; -.
DR OMA; IKQRPYD; -.
DR Proteomes; UP000000809; Chromosome.
DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00425; NqrA; 1.
DR InterPro; IPR008703; NqrA.
DR InterPro; IPR022615; NqrA_C_domain.
DR PANTHER; PTHR37839; PTHR37839; 1.
DR Pfam; PF05896; NQRA; 1.
DR Pfam; PF11973; NQRA_SLBB; 1.
DR TIGRFAMs; TIGR01936; nqrA; 1.
PE 3: Inferred from homology;
KW Ion transport; NAD; Reference proteome; Sodium; Sodium transport;
KW Translocase; Transport; Ubiquinone.
FT CHAIN 1..446
FT /note="Na(+)-translocating NADH-quinone reductase subunit
FT A"
FT /id="PRO_0000214201"
SQ SEQUENCE 446 AA; 48168 MW; 5C5287CB77C4932D CRC64;
MITIKKGLNL PISGSPEQVI RDGNAITEVA LLGEEYVGMR PSMKVREGDV VKKGQVLFED
KKNPGVVFTA PASGTVTAIH RGAKRVLQSV VIKIEGNEQI TFEKYTTEQL NQLTSEQVRQ
NLQASGLWTA LRTRPFSKVP AVDATPVSIF VNAMDTNPLC ADPQVIVQQS AQAFEAGLTV
LSRLHEGKVY LCKAANASIP SPSIANLDVK EFAGPHPAGL SGTHIHFIDP VSATKFVWYI
NYQDVIAVGK LFTTGELDVS RVVSLAGPQV KNPRLVRTVL GANLSQLTAN EVKDGENRVI
SGSVLSGAKA AGPVDYLGRY ALQVSVLEEG REKEFLGWIM PGANKYSLSR TVLGHFSKKL
FNFTTALNGG ERAMVPIGAY ERVMPLDIIP TLLLRDLAAG DTDSAQALGC LELDEEDLAL
CTFVCPGKNE YGPLLRQALD KIEKEG
