ID   NQRA_PSEAE              Reviewed;         445 AA.
AC   Q9HZK6;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=PA2999;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE004091; AAG06387.1; -; Genomic_DNA.
DR   PIR; H83272; H83272.
DR   RefSeq; NP_251689.1; NC_002516.2.
DR   RefSeq; WP_003113983.1; NZ_QZGE01000009.1.
DR   AlphaFoldDB; Q9HZK6; -.
DR   SMR; Q9HZK6; -.
DR   STRING; 287.DR97_4939; -.
DR   PaxDb; Q9HZK6; -.
DR   PRIDE; Q9HZK6; -.
DR   DNASU; 880558; -.
DR   EnsemblBacteria; AAG06387; AAG06387; PA2999.
DR   GeneID; 880558; -.
DR   KEGG; pae:PA2999; -.
DR   PATRIC; fig|208964.12.peg.3147; -.
DR   PseudoCAP; PA2999; -.
DR   HOGENOM; CLU_046656_0_0_6; -.
DR   InParanoid; Q9HZK6; -.
DR   OMA; IKQRPYD; -.
DR   PhylomeDB; Q9HZK6; -.
DR   BioCyc; PAER208964:G1FZ6-3051-MON; -.
DR   PHI-base; PHI:8945; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Reference proteome; Sodium; Sodium transport;
KW   Translocase; Transport; Ubiquinone.
FT   CHAIN           1..445
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_0000214202"
SQ   SEQUENCE   445 AA;  48081 MW;  ED0468D06559B701 CRC64;
     MIKIKRGLDL PISGAPEQRI EAARPVRSVA LIGFDYHGMK PTMAVQVGDR VKLGQVLFTD
     KKNPSVSYTA PGAGVVSAIH RGEKRVLQSV VIDLDGDEQL EFARYPADKL ATLSAEQVRD
     NLLQSGLWTA LRTRPFSKVP DPESSPSSIF VTAIDTQPLA ADPQVVIAEQ GEAFQAGLTV
     LGRLARVFLC KAEGVSLPGE ALSGVTAQAF SGPHPAGLPG THIHFLDPVG AGKSVWNLNY
     QDVIAIGKLF TTGQLWTERV IALAGPVVEK PRLVRTRLGA NLDELAAGQL QPGNNRLISG
     SVLGGRTAHG AYAYLGRYHL QLSCLKEGDQ REFLHYLRAG VEKHSLLNVF VSRLLGGKRF
     AFTTSTNGSP RAMVPVGNYE AVMPLDILPT QLLRYLIVGD TEMAQKLGAL ELDEEDLALC
     SYVCAGKYEY GPILRDNLAR IEQEG